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Related Experiment Videos

Immunologic responses following serial skin testing.

R W Steele, B L Crabtree, G R Smith

    Journal of Immunological Methods
    |February 12, 1986
    PubMed
    Summary
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    Serial skin testing with varicella-zoster (VZ) antigens did not alter immune assays, unlike tetanus toxoid (TT). VZ antigen is ideal for immune monitoring without significantly affecting in vitro results.

    Area of Science:

    • Immunology
    • Dermatology
    • Vaccinology

    Background:

    • Intradermal skin testing is used to assess immune responses.
    • Understanding the impact of repeated antigen exposure is crucial for accurate immune monitoring.

    Purpose of the Study:

    • To evaluate the effects of serial intradermal skin testing with tetanus toxoid (TT) and varicella-zoster (VZ) antigens on immune function.
    • To determine the suitability of VZ antigen for repeated immune monitoring.

    Main Methods:

    • Twenty volunteers received weekly intradermal injections of TT and VZ antigens for 7 weeks.
    • Measurements included delayed hypersensitivity skin test responses, in vitro lymphocyte stimulation, and antibody levels.

    Main Results:

    Related Experiment Videos

  • Tetanus toxoid (TT) testing showed increased variability, boosted antibody titers, and altered skin test kinetics.
  • Serial varicella-zoster (VZ) skin testing did not significantly change cellular immune assays.
  • A slight increase in VZ antibodies was observed in one-third of participants after the initial test.

    • Conclusions:

    • Varicella-zoster (VZ) skin test antigen is suitable for monitoring immune function.
    • Repeated VZ skin testing minimally impacts in vitro immune assays, making it reliable for longitudinal studies.