Related Experiment Video
Updated: Jun 9, 2025
11:44
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
Published on: March 30, 2019
7.6K
Complement factor H in molecular regulation of angiogenesis
Jiang Li1,2,3, Kaili Wang1,2, Maria N Starodubtseva4,5
1Laboratory of Translational Medicine in Microvascular Regulation, Institute of Microvascular Medicine, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China.
Medical Review (2021)
|October 24, 2024
Summary
Complement factor H (CFH) inhibits new blood vessel formation (angiogenesis). Loss of CFH promotes angiogenesis, but recombinant CFH protein can reduce it, offering therapeutic potential for related diseases.
Area of Science:
- Biochemistry
- Immunology
- Vascular Biology
Background:
- Angiogenesis is crucial for physiological and pathological processes.
- Complement factor H (CFH) regulates the complement system's alternative pathway.
- CFH dysfunction is linked to pro-angiogenic events and diseases like age-related macular degeneration.
Purpose of the Study:
- To review the molecular mechanisms underlying CFH's anti-angiogenic effects.
- To discuss the regulation of CFH gene expression.
- To explore the therapeutic potential of recombinant CFH in angiogenesis-related diseases.
Main Methods:
- Literature review of molecular mechanisms.
- Analysis of CFH interactions with C-reactive protein, malondialdehyde, and heparan sulfates.
- Examination of studies on CFH-deficient mice and recombinant CFH protein administration.
Main Results:
- Loss of CFH enhances complement activation, producing pro-angiogenic fragments (C3a, C5a, MAC).
- CFH mutations are associated with choroidal neovascularization in age-related macular degeneration.
- Recombinant CFH protein administration reduced angiogenesis in CFH-deficient mice.
Conclusions:
- CFH possesses significant anti-angiogenic properties through complement regulation and molecular interactions.
- Dysfunctional CFH contributes to pathological angiogenesis.
- Recombinant CFH holds promise as a therapeutic agent for angiogenesis-driven diseases.
Related Concept Videos
01:24Regulation of Angiogenesis and Blood Supply
2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
01:10Mechanism of Angiogenesis
5.3K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.3K
01:28Role of Hematopoietic Growth Factors
1.3K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
1.3K
01:01Regulation of Hematopoietic Stem Cells
3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K
02:33Hedgehog Signaling Pathway
7.3K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.3K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
625
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
625