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Cryptococcoid Sweet syndrome: a case report.

Martina Volonté¹, Giacomo Fiandrino², Camilla Vassallo¹

¹Institute of Dermatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Frontiers in Medicine

|October 24, 2024

Summary

Cryptococcoid Sweet syndrome (cSS), a variant of Sweet syndrome, presents with fungal-like structures but negative fungal tests. This report details a cSS case with a favorable outcome, highlighting diagnostic challenges and prognosis.

Keywords:

Sweet syndrome acute febrile neutrophilic dermatosis cryptococcoid Sweet syndrome cryptococcoid acute febrile neutrophilic dermatosis neutrophilic dermatosis

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Area of Science:

Dermatology
Pathology
Infectious Disease

Background:

Sweet syndrome (SS) is an acute febrile neutrophilic dermatosis.
Cryptococcoid Sweet syndrome (cSS) is a rare variant of SS.
cSS presents with atypical histological features mimicking fungal infections.

Observation:

cSS shows capsular and yeast-like structures on microscopy.
Fungal stains and cultures are negative in cSS.
Myeloperoxidase (MPO) staining is typically positive in cSS biopsies.

Findings:

cSS poses diagnostic challenges due to its mimicry of fungal infections.
The rarity and diagnostic latency of cSS are often linked to poor prognosis.
This study reports a case of cSS with a positive clinical outcome.

Implications:

Accurate diagnosis of cSS is crucial for appropriate management.
Understanding cSS variants improves patient outcomes.
Further research into cSS pathogenesis and treatment is warranted.