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Rare and rapidly growing benign neoplasm arising in skull: Melanotic neuroectodermal tumor of infancy: A case report
Abstract:
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare distinctive neoplasm of infants with rapid expansile growth and a high rate of recurrence. Most commonly, the lesion affects the maxilla followed by the skull and orbit. One such case was diagnosed in a 5-month-old boy who presented with rapidly enlarged swelling over the back of the skull. Surgical excision was done. Typical histological features and immunohistochemical studies confirmed the diagnosis.
Insights
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare condition in infants causing rapid skull swelling. Surgical removal and diagnostic studies confirmed this aggressive neoplasm, highlighting its potential for recurrence.
Area of Science:
- Pediatric Oncology
- Pathology
- Neurosurgery
Background:
- Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, aggressive neoplasm predominantly affecting infants.
- This tumor characteristically exhibits rapid growth and a significant propensity for recurrence.
- While commonly impacting the maxilla, MNTI can also occur in other cranial sites.
Observation:
- A 5-month-old male infant presented with a rapidly growing swelling on the posterior aspect of the skull.
- Clinical examination revealed a significant, rapidly enlarging mass.
- The location of the swelling indicated a potential cranial MNTI.
Findings:
- Surgical excision was performed for the cranial mass.
- Histopathological examination revealed characteristic features of MNTI.
- Immunohistochemical studies further supported the diagnosis of melanotic neuroectodermal tumor of infancy.
Implications:
- This case underscores the importance of considering MNTI in the differential diagnosis of rapidly growing infantile cranial masses.
- Prompt surgical intervention is crucial for managing MNTI.
- Understanding the histological and immunohistochemical profile is vital for accurate diagnosis and management of MNTI.
