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Nitric Oxide-Photodelivering Materials with Multiple Functionalities: From Rational Design to Therapeutic
Cristina Parisi1, Francesca Laneri1, Tassia J Martins1
1PhotoChemLab, Department of Drug and Health Sciences, University of Catania, I-95125 Catania, Italy.
ACS Applied Materials & Interfaces
|October 24, 2024
Summary
Researchers engineered light-activated nitric oxide (NO) materials for controlled drug delivery. These biocompatible NO photodonors offer precise therapeutic potential for diseases like cancer and infections.
Area of Science:
- Biomaterials Engineering
- Photomedicine
- Nanotechnology
Background:
- Nitric oxide (NO) is a crucial signaling molecule with therapeutic potential for cancer, infections, and neurodegeneration.
- Challenges in NO therapy include its gaseous nature, short half-life, and precise concentration control.
- Light-activatable NO precursors (NOPDs) offer a solution for controlled NO release.
Purpose of the Study:
- To review recent advancements in engineered materials for light-controlled NO delivery.
- To highlight the design principles of these NO-releasing systems.
- To discuss therapeutic applications, particularly in cancer and bacterial infections.
Main Methods:
- Fabrication of biocompatible materials (nanoparticles, gels, thin films) incorporating NOPDs.
- Utilizing visible/near-infrared light for controlled NO release.
- Integration of NOPDs with imaging and phototherapeutic components.
Main Results:
- Demonstrated successful engineering of light-responsive multifunctional constructs.
- Showcased materials capable of precise spatiotemporal NO delivery.
- Highlighted progress in developing NOPD-based materials over the last five years.
Conclusions:
- Engineered materials with NOPDs offer a promising platform for light-controlled NO-based therapies.
- These systems address key challenges in NO delivery for improved therapeutic efficacy.
- Significant potential exists for applications in oncology and infectious disease treatment.
