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Peptides as Targeting Agents and Therapeutics: A Brief Overview
Jalissa L Warthen1, Michael J Lueckheide1
1Adelphi University, 1 South Avenue, Garden City, New York 11530, United States.
Biomacromolecules
|October 24, 2024
Summary
Peptides offer precise targeting for drug delivery and therapy against cancer and pathogens. Recent research highlights their versatility in mimicking proteins and assembling into novel therapeutic systems.
Area of Science:
- Biotechnology
- Medicinal Chemistry
- Drug Discovery
Background:
- Peptides offer high controllability and specificity for therapeutic applications.
- They can mimic natural protein structures, activate receptors, and form self-assembling conjugates.
- Peptide-based therapeutics are gaining traction due to their targeted action.
Purpose of the Study:
- To review the last decade of research on peptide applications in medicine.
- To explore peptide use in cancer treatment, pathogen control, and organelle targeting.
- To highlight the in vitro and in vivo successes and future potential of therapeutic peptides.
Main Methods:
- Literature review of studies published in the last 10 years.
- Focus on research involving peptide-based therapies and targeting systems.
- Analysis of applications in oncology, infectious diseases, and targeted delivery.
Main Results:
- Demonstrated successful in vitro and in vivo applications of targeting and therapeutic peptides.
- Identified significant progress in peptide-based cancer treatments.
- Showcased peptide efficacy against various pathogens.
- Confirmed successful organelle and organ targeting using peptide conjugates.
Conclusions:
- Peptides are highly promising for developing targeted therapies against cancer and pathogens.
- Their ability to self-assemble and mimic biological structures expands therapeutic possibilities.
- Continued research into peptide applications will yield novel treatments for diverse diseases.
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