Microenvironment-Responsive Hydrogel Enclosed with Bioactive Nanoparticle for Synergistic Postoperative Adhesion...

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Surgical Innovation

Background:

• Postoperative adhesion (PA) is a significant complication following abdominal surgery.
• Current physical barriers are insufficient against diverse pathological factors during PA formation.

Purpose of the Study:

• To develop a multifunctional hydrogel for combined physical and pharmacological therapy to prevent PA.
• To create an "all-in-one" composite hydrogel with anti-adhesion capabilities.

Main Methods:

• Designed bioactive nanoparticles (BNs) with hyaluronic acid, polydopamine (PDA)-coated ZrO2, antimicrobial peptides, and platelet lysates.
• Developed a dual-responsive, injectable hydrogel for controlled BNs delivery and physical barrier formation.
• Utilized PDA to scavenge reactive oxygen species (ROS) and mitigate inflammation.

Main Results:

• The hydrogel effectively isolated injured tissues, acting as a physical barrier.
• BNs targeted pro-inflammatory cells, eliminated bacterial infection, and promoted tissue repair.
• The composite hydrogel demonstrated a significant anti-adhesion effect in a rat model.

Conclusions:

• The multifunctional hydrogel provides both physical barrier and pharmacological effects for PA prevention.
• This strategy represents a promising clinical solution for reducing postoperative adhesions.
• The injectable and responsive nature ensures effective coverage and controlled therapeutic delivery.