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Updated: Jun 9, 2025

Investigating the Phagocytosis of Leishmania using Confocal Microscopy
Published on: July 29, 2021
LC3-associated phagocytosis and human diseases: Insights from mechanisms to therapeutic potential
Xu Chen1,2, Qi Su1, Ruize Gong2
1College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China.
Abstract:
LC3-associated phagocytosis (LAP) is a distinct type of autophagy that involves the sequestration of extracellular material by phagocytes. Beyond the removal of dead cells and cellular debris from eukaryotic cells, LAP is also involved in the removal of a variety of pathogens, including bacteria, fungi, and viruses. These events are integral to multiple physiological and pathological processes, such as host defense, inflammation, and tissue homeostasis. Dysregulation of LAP has been associated with the pathogenesis of several human diseases, including infectious diseases, autoimmune diseases, and neurodegenerative diseases. Thus, understanding the molecular mechanisms underlying LAP and its involvement in human diseases may provide new insights into the development of novel therapeutic strategies for these conditions. In this review, we summarize and highlight the current consensus on the role of LAP and its biological functions in disease progression to propose new therapeutic strategies. Further studies are needed to illustrate the precise role of LAP in human disease and to determine new therapeutic targets for LAP-associated pathologies.
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