Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

1
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
1
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

1
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1
Atherosclerosis II: Clinical manifestations and prevention01:27

Atherosclerosis II: Clinical manifestations and prevention

1
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
1
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

3
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
3
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

1
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
1
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

3
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
3

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elevated IL-6 receptor expression on CD4+ T cells contributes to the increased Th17 responses in patients with chronic hepatitis B.

Virology journal·2011
Same author

Neurochemical plasticity of nitric oxide synthase isoforms in neurogenic detrusor overactivity after spinal cord injury.

Neurochemical research·2011
Same author

[Clinical significance of 5-HT and DA levels in serum and cerebrospinal fluid of the patients with delayed encephalopathy after acute carbon monoxide poisoning].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2011
Same author

Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1(-/-) cells.

American journal of physiology. Cell physiology·2011
Same author

[The association between HBV genotyping and clinical characteristics and expression of TH1/TH2 cytokines].

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology·2011
Same author

Bis[5-(2-pyrid-yl)pyrazine-2-carbonitrile]-silver(I) tetra-fluorido-borate.

Acta crystallographica. Section E, Structure reports online·2011
Same journal

PER1 reduces HIF-1α nuclear accumulation and modulates vascular remodeling in hepatocellular carcinoma.

Molecular and cellular biochemistry·2026
Same journal

FCGR2A promoter variant reveals shared genetic susceptibility between IBD and stroke.

Molecular and cellular biochemistry·2026
Same journal

Chlamydia psittaci induces GSDME-mediated pyroptosis via the ROS-JNK signaling pathway.

Molecular and cellular biochemistry·2026
Same journal

Pentraxin 3 is an inflammation-related biomarker that distinguishes early-stage from mid-advanced cardiovascular-kidney-metabolic syndrome.

Molecular and cellular biochemistry·2026
Same journal

High glucose-induced mitochondrial fission promotes Müller cell activation via suppression of the Hippo pathway.

Molecular and cellular biochemistry·2026
Same journal

Correction to: Estradiol inhibits vascular endothelial cells pro-inflammatory activation induced by C-reactive protein.

Molecular and cellular biochemistry·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.2K

Omics research in atherosclerosis.

Kai-Jiang Tian1,2, Yu Yang2, Guo-Shuai Chen3

  • 1Pathology Department, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.

Molecular and Cellular Biochemistry
|October 24, 2024
PubMed
Summary
This summary is machine-generated.

Atherosclerosis (AS), a chronic inflammatory disease, lacks effective treatments. Omics technologies offer new insights into AS mechanisms and potential therapeutic targets for cardiovascular diseases.

Keywords:
AtherosclerosisGenomicsMetabolomicsMicrobiomicsOmicsProteomicsTranscriptomics

More Related Videos

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

37.1K
Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model
07:49

Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model

Published on: February 14, 2025

350

Related Experiment Videos

Last Updated: Jun 9, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.2K
Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

37.1K
Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model
07:49

Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model

Published on: February 14, 2025

350

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Pathophysiology

Background:

  • Atherosclerosis (AS) is a chronic inflammatory condition underlying cardiovascular diseases, marked by arterial intima lipid deposition, fibrous tissue proliferation, and calcification.
  • The complex pathogenesis of AS, involving oxidative stress, inflammation, and lipid changes, remains incompletely understood.
  • Current prevention and treatment strategies for AS are limited, highlighting the need for novel approaches.

Purpose of the Study:

  • To review the application and impact of omics technologies in atherosclerosis research over the past decade.
  • To identify the current status, challenges, limitations, and future prospects of omics in understanding AS.
  • To highlight potential therapeutic targets for AS-related diseases identified through omics approaches.

Main Methods:

  • Systematic review of research articles published in the last 10 years focusing on omics technologies and atherosclerosis.
  • Analysis of genomic, transcriptomic, proteomic, and metabolomic studies related to AS.
  • Evaluation of the clinical relevance and translational potential of omics findings in AS.

Main Results:

  • Omics technologies (genomics, transcriptomics, proteomics, metabolomics) provide powerful tools for dissecting AS complexity.
  • Significant advancements have been made in identifying molecular pathways and biomarkers associated with AS.
  • Challenges remain in data integration, validation, and clinical translation of omics discoveries.

Conclusions:

  • Omics technologies are revolutionizing atherosclerosis research, offering deeper insights into its pathophysiology.
  • Further research is needed to overcome current limitations and translate omics findings into effective clinical applications.
  • Targeting pathways identified through omics holds promise for developing novel therapeutic strategies for AS and related cardiovascular diseases.