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Omics research in atherosclerosis

Kai-Jiang Tian1,2, Yu Yang2, Guo-Shuai Chen3

  • 1Pathology Department, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.

Molecular and Cellular Biochemistry
|October 24, 2024
PubMed

Insights

Atherosclerosis (AS), a chronic inflammatory disease, lacks effective treatments. Omics technologies offer new insights into AS mechanisms and potential therapeutic targets for cardiovascular diseases.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Pathophysiology

Background:

  • Atherosclerosis (AS) is a chronic inflammatory condition underlying cardiovascular diseases, marked by arterial intima lipid deposition, fibrous tissue proliferation, and calcification.
  • The complex pathogenesis of AS, involving oxidative stress, inflammation, and lipid changes, remains incompletely understood.
  • Current prevention and treatment strategies for AS are limited, highlighting the need for novel approaches.

Purpose of the Study:

  • To review the application and impact of omics technologies in atherosclerosis research over the past decade.
  • To identify the current status, challenges, limitations, and future prospects of omics in understanding AS.
  • To highlight potential therapeutic targets for AS-related diseases identified through omics approaches.

Main Methods:

  • Systematic review of research articles published in the last 10 years focusing on omics technologies and atherosclerosis.
  • Analysis of genomic, transcriptomic, proteomic, and metabolomic studies related to AS.
  • Evaluation of the clinical relevance and translational potential of omics findings in AS.

Main Results:

  • Omics technologies (genomics, transcriptomics, proteomics, metabolomics) provide powerful tools for dissecting AS complexity.
  • Significant advancements have been made in identifying molecular pathways and biomarkers associated with AS.
  • Challenges remain in data integration, validation, and clinical translation of omics discoveries.

Conclusions:

  • Omics technologies are revolutionizing atherosclerosis research, offering deeper insights into its pathophysiology.
  • Further research is needed to overcome current limitations and translate omics findings into effective clinical applications.
  • Targeting pathways identified through omics holds promise for developing novel therapeutic strategies for AS and related cardiovascular diseases.

Keywords:
AtherosclerosisGenomicsMetabolomicsMicrobiomicsOmicsProteomicsTranscriptomics

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