Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electroconvulsive Therapy01:30

Electroconvulsive Therapy

25
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
25
The Placebo Effect01:54

The Placebo Effect

6.1K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal associations of physical and emotional distress tolerance with pain intensity and pain-related disability in United States combat veterans.

Journal of behavioral medicine·2026
Same author

Graduated exposure to traumatic events decreases distress during prolonged exposure therapy for posttraumatic stress disorder.

Journal of behavioral medicine·2026
Same author

Gender, headache frequency, and headache intensity predict psychosocial functioning and quality of life in a sample of United States combat veterans.

Journal of behavioral medicine·2026
Same author

Digital interventions targeting the impact of stress on stress-related mental health outcomes in military personnel and veterans: a systematic review.

Journal of behavioral medicine·2026
Same author

Organizational readiness for implementing comprehensive and tailored Veteran suicide prevention programming in community agencies.

Translational behavioral medicine·2026
Same author

The longitudinal relations between physical activity, inflammation, and depression in the Health and Retirement Study.

PLOS mental health·2026
Same journal

Digitalization of Intervention Delivery and Its Impact on the Effects of Interventions for Mental Well-Being in Higher Education Students: Systematic Review and Meta-Analysis Protocol.

JMIR research protocols·2026
Same journal

Artificial Intelligence-Mediated Discharge Document for Accessible Health Care (AIM-HEALTH): Protocol for a Prospective, Observational, Noninterventional Study.

JMIR research protocols·2026
Same journal

An Innovative Model of Stroke Care for Rapid Assessment and Discharge of Patients With Transient Ischemic Attack and Stroke in Northeastern Ontario: Protocol for the Implementation and Evaluation of MOTIVE (Mobile Transient Ischemic Attack and Stroke With Adaptive Workflow) Team.

JMIR research protocols·2026
Same journal

Integrative Traditional East Asian Medicine-Based Adjunctive Therapies for Patients With Prostate Cancer Undergoing Standard Cancer Treatment: Protocol for a Systematic Review and Meta-Analysis of Randomized Controlled Trials.

JMIR research protocols·2026
Same journal

Targeted Next-Generation Sequencing for Improved Clinical Outcomes in People Living With Rare Diseases in Global South: Protocol for a Systematic Review and Meta-Synthesis.

JMIR research protocols·2026
Same journal

Evaluation and Comparison of Latent Health Risk Prediction Models for Clinical Triage: Protocol for a Mixed Methods Study.

JMIR research protocols·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2025

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure
08:20

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Published on: January 18, 2021

3.9K

The Evaluation of a Web-Based Intervention (Deprexis) to Decrease Depression and Restore Functioning in Veterans:

Rahel Pearson1, Christopher G Beevers2, Joseph Mignogna3,4

  • 1Veterans Integrated Service Network 17 Center of Excellence for Research on Returning War Veterans, Central Texas Veterans Affairs Healthcare System, Waco, TX, United States.

JMIR Research Protocols
|October 24, 2024
PubMed
Summary
This summary is machine-generated.

This study evaluates Deprexis, a computerized intervention for veterans experiencing depressive symptoms. Early findings suggest potential for accessible, low-resource mental health treatment, improving veteran functioning.

Keywords:
RCTdepressioneHealthmental healthmobile phonerandomized controlled trial

More Related Videos

Virtual Prism Adaptation Therapy: Protocol for Validation in Healthy Adults
06:12

Virtual Prism Adaptation Therapy: Protocol for Validation in Healthy Adults

Published on: February 12, 2020

6.8K
Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment
08:25

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Published on: December 6, 2024

313

Related Experiment Videos

Last Updated: Jun 9, 2025

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure
08:20

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Published on: January 18, 2021

3.9K
Virtual Prism Adaptation Therapy: Protocol for Validation in Healthy Adults
06:12

Virtual Prism Adaptation Therapy: Protocol for Validation in Healthy Adults

Published on: February 12, 2020

6.8K
Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment
08:25

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Published on: December 6, 2024

313

Area of Science:

  • Mental Health
  • Digital Health Interventions
  • Veteran Healthcare

Background:

  • Depressive symptoms are prevalent in veterans, often leading to increased disability and suicidal ideation.
  • Untreated depression in veterans can result in severe long-term consequences, including chronic illness and functional impairment.
  • Computerized interventions offer a scalable solution for veterans with mild to moderate depression due to accessibility and resource efficiency.

Purpose of the Study:

  • To assess the efficacy of Deprexis, a digital intervention, for treating depressive symptoms in veterans.
  • To evaluate the impact of Deprexis on psychosocial functioning among the veteran population.
  • To provide initial evidence for self-guided, computerized treatments in veteran mental healthcare.

Main Methods:

  • Recruitment of veterans via the Department of Veterans Affairs electronic medical record and clinics.
  • Qualitative interviews with a subset of veterans (n=16-20) to gauge treatment acceptability.
  • Randomized controlled trial assigning 132 veterans with mild to moderate depression to Deprexis or treatment-as-usual.

Main Results:

  • Data collection is ongoing from October 2024 to April 2029.
  • Initial participant recruitment is underway, with data analysis planned for June 2029.
  • Preliminary results are anticipated in November 2029, pending data analysis.

Conclusions:

  • The study aims to establish the effectiveness of computerized interventions for veteran depression.
  • Successful outcomes could enhance veteran access to low-cost, readily available psychosocial support.
  • This research addresses a gap in understanding digital mental health solutions for veterans.