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Cost-effectiveness Analysis Comparing Conventional and Digital Software Supported Management for Hypothyroidism.

Jung Hyun Kim1, Jaeyong Shin2,3, Man S Kim4

  • 1Division of Tourism and Wellness, Hankuk University of Foreign Studies (HUFS), Yongin 17035, Republic of Korea.

The Journal of Clinical Endocrinology and Metabolism
|October 24, 2024
PubMed
Summary

Wearable digital monitoring for hypothyroidism is cost-effective, improving quality of life. This approach offers a favorable incremental cost-effectiveness ratio (ICER) compared to standard care.

Keywords:
QALYscost-effectiveness analysisdigital monitoring solutionhypothyroidism

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Area of Science:

  • Endocrinology
  • Digital Health
  • Health Economics

Background:

  • Wearable devices can monitor thyroid function via heart rate correlation.
  • Hypothyroidism management can be enhanced by digital monitoring solutions.

Purpose of the Study:

  • To assess the cost-effectiveness of a wearable/mobile-based digital monitoring solution for hypothyroidism.
  • Compare digital monitoring to conventional hypothyroidism management.

Main Methods:

  • A Markov state-transition model simulated 10,000 patients with hypothyroidism.
  • Evaluated cost-effectiveness from a healthcare perspective, using a 4.5% discount rate and 2022 cost adjustments.
  • Calculated lifetime outcomes and incremental cost-effectiveness ratios (ICERs), with sensitivity analyses.

Main Results:

  • The digital monitoring group gained 0.65 quality-adjusted life-years (QALYs) at an incremental cost of $11,700.87.
  • The ICER was $17,988.97 per QALY gained, indicating cost-effectiveness.
  • Digital monitoring was optimal in 99% of iterations against a willingness-to-pay threshold of $32,255/QALY.

Conclusions:

  • Digital monitoring solutions are cost-effective for hypothyroidism management compared to standard care.
  • The cost and sensitivity of the digital solution are critical for cost-effectiveness.
  • Balancing digital monitoring costs, hormonal precision, and clinical effectiveness is essential.