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Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
Published on: June 5, 2020
Industrial Genotoxicology Group: 36th Annual Meeting Report
Darren Kidd1, Ian Crooks2, Angela Saccardo3
1Labcorp Early Development Laboratories Ltd., Otley Road, Harrogate, North Yorkshire, HG3 1PY, United Kingdom.
Abstract:
The proceedings of the 36th annual meeting of the Industrial Genotoxicology Group (IGG) are shared here. The meeting held at Lhasa Limited, Leeds, UK on 28 November 2023, focussed on two aspects; new approach methodologies (NAMs), including those for the assessment of non-standard modalities such as gas-vapour assessments and nanomaterials, and addressing the regulatory challenges associated with understanding the genotoxic and carcinogenic potential of N-nitrosamines and N-nitrosamine impurities. New approach methodologies, such as error-corrected sequencing and enhanced Ames tests that may help address these challenges were also discussed.

