Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

1.2K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.2K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

3
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
3
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.7K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
Lung Capacity01:47

Lung Capacity

49.6K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
49.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond spirometry in COPD: expanding the diagnostic paradigm.

ERJ open research·2026
Same author

Performance of multivariable risk prediction algorithms in predicting COPD exacerbations: a population-based study.

Thorax·2026
Same author

Defining disease stability in COPD: Evidence from Phase 3 clinical trials.

American journal of respiratory and critical care medicine·2026
Same author

Exploring COPD Participants' Experiences in a Comprehensive Telewellness Program within a Mixed-Disability Cohort: A Qualitative Study.

International journal of chronic obstructive pulmonary disease·2026
Same author

Rural <i>versus</i> urban living and COPD: a systematic review.

European respiratory review : an official journal of the European Respiratory Society·2026
Same author

Life's Essential 8 and Risk of Severe COVID-19 Among Adults Without Clinical Cardiovascular Disease: The C4R Study.

Journal of the American Heart Association·2026
Same journal

Cell Lysis Pneumopathy in Patients with Hyperleukocytic Acute Myeloid Leukemia.

Annals of the American Thoracic Society·2026
Same journal

Morphologic evaluation in fibrotic hypersensitivity pneumonitis: the era of quantitative CT is upon us.

Annals of the American Thoracic Society·2026
Same journal

"From Guidelines to Practice: The PuSHCon Health-Coach Model for COPD and Asthma".

Annals of the American Thoracic Society·2026
Same journal

Fine particulate matter exposure and long-term lung-function trajectory in adults with cystic fibrosis.

Annals of the American Thoracic Society·2026
Same journal

Lung Health Lessons Learned Abroad Are Critical To Understanding Lung Health at Home.

Annals of the American Thoracic Society·2026
Same journal

Impact of Elexacaftor/Tezacaftor/Ivacaftor (ETI) on Airway and Aystemic Inflammation in Cystic Fibrosis: A Systematic Review.

Annals of the American Thoracic Society·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2025

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
10:11

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

19.1K

Low Lung Function Is Associated with High Population Attributable Fraction for Cardiovascular Mortality.

Surya P Bhatt1, Chaoqi Wu2, Yifei Sun2

  • 1Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Lung Analytics and Imaging Research, University of Alabama at Birmingham, Birmingham, Alabama.

Annals of the American Thoracic Society
|October 24, 2024
PubMed
Summary
This summary is machine-generated.

Low lung function significantly contributes to coronary heart disease (CHD) mortality, ranking as a major risk factor. This finding highlights the importance of lung function assessment in cardiovascular risk evaluation.

Keywords:
coronary heart diseaselung functionpopulation attributable fraction

More Related Videos

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters
05:18

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters

Published on: July 12, 2024

249
Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
08:44

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Published on: February 2, 2024

649

Related Experiment Videos

Last Updated: Jun 9, 2025

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
10:11

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

19.1K
Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters
05:18

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters

Published on: July 12, 2024

249
Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
08:44

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Published on: February 2, 2024

649

Area of Science:

  • Cardiology
  • Pulmonology
  • Epidemiology

Background:

  • Chronic lung diseases are linked to increased coronary heart disease (CHD) mortality.
  • The population attributable fraction (PAF) of impaired lung function for CHD mortality is not well-established.
  • Understanding lung function's role in cardiovascular risk is crucial for public health.

Purpose of the Study:

  • To determine the population attributable fraction (PAF) of low lung function for coronary heart disease (CHD) mortality.
  • To compare the impact of low lung function with other established cardiovascular risk factors.

Main Methods:

  • Pooled data from eight U.S. general population cohorts, including spirometry and clinical data.
  • Defined impaired lung function as forced expiratory volume in 1 second (FEV1) and/or forced vital capacity ≤95% predicted.
  • Utilized cause-specific proportional hazards and Fine-Gray models, adjusting for multiple cardiovascular risk factors and competing risks.

Main Results:

  • Low FEV1 (≤95% predicted) was associated with a 1.30 hazard ratio for CHD mortality.
  • The PAF for low FEV1 was 12%, positioning it as the third leading attributable risk factor for CHD mortality after hypertension and diabetes.
  • In active smokers, low FEV1 accounted for 14% of CHD mortality, ranking second after hypertension.

Conclusions:

  • Reduced lung function, even within clinically normal ranges, is a significant attributable risk factor for CHD mortality.
  • Lung function assessment should be integrated into cardiovascular risk stratification strategies.
  • This research underscores the interconnectedness of respiratory and cardiovascular health.