Related Experiment Video

Updated: Jun 9, 2025

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
06:06

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

Published on: September 11, 2020

1.7K

Epidemiology of Streptococcus pyogenes Disease before, during, and after COVID-19 Pandemic, Germany, 2005-2023

Irene Burckhardt, Florian Burckhardt

    Emerging Infectious Diseases
    |October 24, 2024
    PubMed

    Insights

    Streptococcus pyogenes cases increased annually until COVID-19. Invasive disease risk was higher in males and older individuals, influenced by the year of diagnosis.

    Area of Science:

    • Infectious Diseases
    • Microbiology
    • Epidemiology

    Background:

    • Streptococcus pyogenes (group A Streptococcus) is a significant human pathogen.
    • Invasive infections can lead to severe morbidity and mortality.
    • Understanding long-term trends and risk factors is crucial for public health.

    Purpose of the Study:

    • To analyze trends in Streptococcus pyogenes infections over 19 years.
    • To identify demographic and temporal risk factors for invasive streptococcal disease.

    Main Methods:

    • Retrospective analysis of 3,081 invasive and noninvasive Streptococcus pyogenes cases.
    • Data collected from January 2005 to December 2023 at a tertiary care hospital.
    • Statistical analysis to determine factors influencing invasive disease.

    Main Results:

    • A consistent annual increase in Streptococcus pyogenes cases from 2005 until the COVID-19 pandemic.
    • Significant associations found between invasive disease and year, male sex, and older age.
    • The COVID-19 pandemic appeared to interrupt the increasing trend.

    Conclusions:

    • Streptococcus pyogenes infections showed an upward trend prior to the pandemic.
    • Male sex and advanced age are identified risk factors for invasive Streptococcus pyogenes disease.
    • Further research is needed to understand the impact of the pandemic on infection dynamics.
    Keywords:
    COVID-19GermanySARS-CoV-2Streptococcus pyogenesbacteriacoronavirus diseasedisease outbreakepidemiologygroup A Streptococcuslogistic modelrespiratory infectionssevere acute respiratory syndrome coronavirus 2streptococciviruseszoonoses

    More Related Videos

    Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells09:25

    Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells

    Published on: August 19, 2016

    11.0K
    A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness12:21

    A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

    Published on: September 28, 2022

    2.4K

    Related Concept Videos

    Steps in Outbreak Investigation01:18

    Steps in Outbreak Investigation

    In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
    107
    Bacterial Phylum Spirochaetes01:30

    Bacterial Phylum Spirochaetes

    Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
    Acute Pharyngitis01:30

    Acute Pharyngitis

    Introduction
    Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
    Classification
    Acute pharyngitis can be categorized based on its underlying cause:
    454
    Urinary Tract Infection II: Pathophysiology01:25

    Urinary Tract Infection II: Pathophysiology

    The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
    1
    Factors Affecting the Risk of Infection01:26

    Factors Affecting the Risk of Infection

    The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
    The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
    11.5K
    Infection01:20

    Infection

    When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
    The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
    7.7K