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Increased occurrence of microstate class B as the independent risk factor for persistent psychiatric symptoms related

Qinlian Huang1, Linqi Liu1, Lihong Huang2

  • 1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China.

Brain Research Bulletin
|October 24, 2024
PubMed
Abstract

Insights

Increased EEG microstate class B occurrence is linked to persistent Omicron-related Psychiatric Symptoms (ORPS) and predicts poorer outcomes. This finding may help in early assessment and prognosis of ORPS severity.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Omicron-related Psychiatric Symptoms (ORPS) present a growing clinical challenge.
  • Understanding the neurophysiological underpinnings of ORPS is crucial for effective management.
  • EEG microstates offer a window into brain functional dynamics.

Purpose of the Study:

  • To investigate EEG microstate characteristics in patients with persistent ORPS.
  • To explore the correlation between EEG microstate features and ORPS severity.
  • To identify potential biomarkers for ORPS prognosis.

Main Methods:

  • Study included 31 ORPS patients, divided into remission and non-remission groups.
  • Multivariate logistic models analyzed risk factors for non-remission.
  • Spearman rank correlation assessed the link between microstate class B and symptom severity (BPRS).

Main Results:

  • An increased occurrence of EEG microstate class B was significantly associated with a higher likelihood of non-remission of ORPS.
  • A moderate positive correlation was found between microstate class B occurrence and BPRS scores at admission.
  • Patients with more frequent microstate class B showed more severe psychiatric symptoms.

Conclusions:

  • Increased EEG microstate class B occurrence is an independent risk factor for ORPS non-remission.
  • Microstate class B shows potential as a biomarker for ORPS symptom severity.
  • Early identification of microstate class B may aid in assessing ORPS severity and prognosis.
Keywords:
EEGEEG microstateOmicronPsychiatric symptomsSARS-Cov-2

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