Endoperoxidases in biosynthesis of endoperoxide bonds

Endoperoxides are important sources of ideas for drug discovery. Endoperoxide bonds are considered to be the cause of the interesting biological activities of endoperoxides, but there is limited knowledge regarding the biosynthetic mechanisms of most endoperoxide bonds. In this minireview, we summarize current knowledge about the biosynthesis of endoperoxides in nature and focus our discussion on plant-derived endoperoxides. In short, plants have evolved two systems, photocatalysis and enzyme catalysis, to catalyse the synthesis of endoperoxide bonds. Iron-dependent oxygenases, represented by the α-ketoglutarate (α-KG)-dependent dioxygenase (2-ODD) family, are most likely involved in the enzyme-catalysed reactions of endoperoxides in plants. Moreover, Nardostachys jatamansi (D.Don) DC, a plant native to the Himalayan alpine region, is strongly recommended for use in the discovery of plant-derived endoperoxidases.