Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

252
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
252
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

322
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
322
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

145
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
145

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-covalent interactions between lignin and cellulase: From molecular mechanisms to precision regulation.

Bioresource technology·2026
Same author

Karst groundwater cycle model, hydrochemical characteristics and tectonic controls of the Shuimocao karst spring basin in the Northern Taihang Mountains, China.

Scientific reports·2026
Same author

AI-driven therapeutic antisense oligonucleotide for processing-deficient progeroid laminopathies.

Med (New York, N.Y.)·2026
Same author

Retraction notice to "Scenario analysis on optimal farmed-fish-species composition in China: A tentative theoretical methodology to benefit wild-fishery stock, water conservation, economic and protein outputs under the context of climate change" [Sci. Total Environ. 806 (2022) 150600].

The Science of the total environment·2026
Same author

Hydrated Network Interphase with Dynamic Negatively Charged Microregion Enables Ultra-Stable Aqueous Zinc-Ion Batteries.

Nano-micro letters·2026
Same author

The Recent Advances in the Development of Multifunctional Carbon Dot Nanozymes with Defined Catalytic Mechanisms for Biomedical Applications.

ACS applied bio materials·2026
Same journal

Corrigendum to "Choroid plexus enlargement correlates with cognitive impairment and brain atrophy in patients with mood disorders" [J. Affect. Disord. 379 (2025) 370-378].

Journal of affective disorders·2026
Same journal

Long-term trajectories of basal metabolic rate and risk of depressive symptoms: evidence from three large population-based cohorts.

Journal of affective disorders·2026
Same journal

An implementation "Field Trial" of DBT for adolescents with bipolar disorder: Training procedures and therapist outcomes.

Journal of affective disorders·2026
Same journal

Anxiety and depression associated oral health problems in pediatric populations: A systematic review and meta-analysis.

Journal of affective disorders·2026
Same journal

Corrigendum to "Suicidal ideation in the postpartum period: A population-based study of prevalence and risk factors using data from two national maternity surveys in England" [J. Affect. Disord. 389 (2025) 119707].

Journal of affective disorders·2026
Same journal

Suicide mortality in Brazil: Post-pandemic excess mortality and spatial inequalities.

Journal of affective disorders·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2025

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
11:50

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging

Published on: February 4, 2022

3.9K

Cerebral cortex changes in FD, IBS, and GERD: A Mendelian randomization study.

Kai-Yue Huang1, Jia-Yan Hu2, Mi Lv1

  • 1Institute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China; Graduate School, China Academy of Chinese Medical Sciences, Beijing, China.

Journal of Affective Disorders
|October 24, 2024
PubMed
Summary
This summary is machine-generated.

Common gastrointestinal disorders like functional dyspepsia (FD), irritable bowel syndrome (IBS), and gastroesophageal reflux disease (GERD) are linked to changes in brain structure. These gut-brain axis effects may increase risks for mental illness and cognitive issues.

Keywords:
Brain structureEuropeanFunctional gastrointestinal disordersMRIMendelian randomization

More Related Videos

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
09:57

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index

Published on: January 2, 2012

27.8K
Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
07:29

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Published on: December 29, 2023

603

Related Experiment Videos

Last Updated: Jun 9, 2025

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
11:50

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging

Published on: February 4, 2022

3.9K
How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
09:57

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index

Published on: January 2, 2012

27.8K
Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
07:29

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Published on: December 29, 2023

603

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Genetics

Background:

  • Functional gastrointestinal disorders (FGIDs) are associated with anxiety and depression, but causality is unclear.
  • Previous studies suggest a link between FGIDs and mental health conditions.
  • The brain-gut axis is a key area of research for understanding these connections.

Purpose of the Study:

  • To investigate the causal relationship between common gastrointestinal disorders and human cortical structures.
  • To utilize Mendelian randomization (MR) to assess genetic predispositions to FGIDs and their impact on brain architecture.
  • To clarify the direction of the relationship between gut health and brain structure.

Main Methods:

  • Genome-wide association study (GWAS) data for functional dyspepsia (FD), irritable bowel syndrome (IBS), and gastroesophageal reflux disease (GERD) from large European cohorts.
  • Analysis of cerebral cortical thickness (TH) and surface area (SA) data from 51,665 MRI scans.
  • Application of Mendelian randomization (MR) with inverse-variance weighted, weighted median, and MR-Egger methods to infer causality, alongside heterogeneity and pleiotropy assessments.

Main Results:

  • Functional dyspepsia (FD) was associated with decreased cortical thickness in the rostral anterior cingulate cortex.
  • Irritable bowel syndrome (IBS) showed associations with reduced surface area in the pars triangularis, precuneus, and superior frontal regions.
  • Gastroesophageal reflux disease (GERD) was linked to an increased surface area in the inferior temporal region.

Conclusions:

  • Functional dyspepsia, irritable bowel syndrome, and gastroesophageal reflux disease can impact cerebral cortex architecture via the brain-gut axis.
  • These alterations in brain structure may contribute to an increased risk of mental illness.
  • The findings suggest a potential link between gut disorders and cognitive impairment.