Involvement of β-catenin expression in hepatocellular carcinoma prognosis in a cohort of patients undergoing curative treatment
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View abstract on PubMed
Summary
This summary is machine-generated.Overexpression of beta-catenin in hepatocellular carcinoma correlates with worse disease-free survival. Combining this with a high neutrophil-lymphocyte ratio further worsens prognosis for liver cancer patients.
Area Of Science
- Hepatobiliary Surgery
- Surgical Oncology
- Molecular Oncology
Background
- Hepatocellular carcinoma (HCC) is a prevalent epithelial liver tumor with incompletely defined prognostic markers.
- Mutations and overexpression of beta-catenin are observed in HCC.
- Established prognostic markers for HCC require further elucidation.
Purpose Of The Study
- To investigate the correlation between molecular beta-catenin expression in HCC and established prognostic markers.
- To assess the prognostic significance of beta-catenin in HCC patients.
Main Methods
- Prospective observational cohort study involving adult HCC patients.
- Intraoperative sampling of nontumor and tumor liver parenchyma.
- Correlation analysis of beta-catenin expression with known prognostic markers.
Main Results
- A total of 48 HCC samples met inclusion criteria, with 31 on cirrhotic livers (64.6%) and 17 on non-cirrhotic livers (35.4%).
- Overexpression of beta-catenin and elevated neutrophil/lymphocyte ratio are independently linked to disease-free survival.
- Both beta-catenin overexpression and molecular repression showed independent relationships.
Conclusions
- Molecular overexpression of beta-catenin in HCC is associated with poorer disease-free survival compared to nontumor tissue.
- The combination of beta-catenin overexpression and a high neutrophil-lymphocyte ratio exacerbates the negative prognosis in HCC.
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