Related Experiment Video
Updated: May 5, 2026

13:47
Establishment of an In vitro System to Study Intracellular Behavior of Candida glabrata in Human THP-1 Macrophages
Published on: December 11, 2013
11.3K
V.R. Khanolkar's initial years as pathologist and researcher in India: 1924-1941
Sanjay A Pai1, Dhaneshwar N Lanjewar2, Amita S Joshi3
1Department of Pathology, Manipal Hospital, Yeshwanthpur, Bengaluru 560055, Karnataka, India.
The National Medical Journal of India
|October 24, 2024
Summary
Vasant Ramji Khanolkar, India's first pathologist, conducted significant research after joining Tata Memorial Hospital. His early career showed limited research output, the reasons for which remain unclear.
Area of Science:
- Pathology
- Medical History
- Scientific Research
Background:
- Vasant Ramji Khanolkar was a pioneering Indian pathologist and researcher in cancer, genetics, and epidemiology.
- His most notable work occurred after he became Director of Laboratories at Tata Memorial Hospital, Mumbai.
- There is a perceived gap in documented research from the first 17 years of his career at J.J. Hospital and K.E.M. Hospital, Mumbai.
Observation:
- The study investigated Khanolkar's research output prior to his tenure at Tata Memorial Hospital.
- PubMed searches and reviews of abstracts from the Teaching Pathologists Association, Bombay, were conducted.
- Autopsy registers from J.J. Hospital and K.E.M. Hospital were examined for relevant information.
Findings:
- Khanolkar conducted preliminary research on anemia and experimental pathology during his time at K.E.M. Hospital.
- Histological examinations were notably absent in most autopsies at J.J. Hospital during his professorship.
- Histology was performed on autopsies at K.E.M. Hospital during the same period.
Implications:
- This research attempts to fill the gap in understanding Khanolkar's early scientific contributions.
- The findings highlight variations in pathological practices between J.J. Hospital and K.E.M. Hospital.
- The reasons behind Khanolkar's delayed research productivity in his initial academic positions remain an open question.
Related Concept Videos
Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
Mechanisms of Retrovirus-induced Cancers
5.0K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.0K
Rous Sarcoma Virus (RSV) and Cancer
5.0K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.0K
History of Microbiology
6
Microbiology, a scientific field dedicated to the study of microorganisms, has undergone profound development since its inception in the 17th century. Its history is marked by key discoveries and technological advancements that have shaped our understanding of life at the microscopic level and transformed medicine, agriculture, and industry.Early Foundations of MicrobiologyThe early foundations of microbiology were built on groundbreaking observations and the development of pioneering...
6

