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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

1.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Inflammation01:38

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Overview
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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Updated: Jun 9, 2025

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
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Inflammation and resolution in obesity.

Matúš Soták1, Madison Clark2,3, Bianca E Suur2,3

  • 1Department of Clinical Immunology and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.

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|October 25, 2024
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Summary

Targeting inflammation in obesity is key for preventing cardiovascular disease and type 2 diabetes. New strategies focus on resolving inflammation, not just blocking it, to improve metabolic health.

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Area of Science:

  • Biomedical Science
  • Immunology
  • Metabolic Disease Research

Background:

  • Prolonged inflammation, especially in adipose tissue, is a key driver of obesity-related cardiovascular disease and type 2 diabetes.
  • Current anti-inflammatory drugs have limitations, including adverse effects and failure to modulate inflammation resolution.

Purpose of the Study:

  • To review clinical strategies for managing obesity-related inflammation.
  • To explore targeting pro-inflammatory pathways and enhancing endogenous resolution mechanisms.

Main Methods:

  • Review of clinical trials targeting pro-inflammatory mediators (IL-1β, NLRP3 inflammasome, TNF, IL-6).
  • Examination of approaches utilizing endogenous inflammation resolution pathways.
  • Discussion of challenges in biomarker development for inflammation monitoring.

Main Results:

  • Approved drugs target pro-inflammatory pathways but have side effects and don't promote resolution.
  • Pro-resolving mediators show therapeutic potential in preclinical models for insulin resistance and atherosclerosis.
  • Clinical efforts are underway to target both inflammation and resolution phases.

Conclusions:

  • Modulating inflammation resolution offers therapeutic promise for obesity-related cardiometabolic diseases.
  • Development of precise biomarkers is crucial for personalized treatment strategies.
  • Future research should focus on enhancing resolution pathways and improving inflammation monitoring.