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Related Concept Videos

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

3.2K
Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
3.2K

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Related Experiment Video

Updated: Jun 9, 2025

Manual Blot-and-Plunge Freezing of Biological Specimens for Single-Particle Cryogenic Electron Microscopy
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Manual Blot-and-Plunge Freezing of Biological Specimens for Single-Particle Cryogenic Electron Microscopy

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Cryo-electron microscopy in color

Henning Stahlberg1,2

  • 1Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland. henning.stahlberg@epfl.ch.

Nature Methods
|October 25, 2024
PubMed
Summary

No abstract available in PubMed .

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