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Efficacy of atorvastatin on renal function in patients with contrast-induced nephropathy after percutaneous coronary

Heng Li1, Hongen Wang1, Siqi Ren1

  • 1Department of Cardiology, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, 215101, Jiangsu Province, China.

Journal of Cardiothoracic Surgery
|October 25, 2024
PubMed

Insights

High-dose atorvastatin effectively protects kidney function in patients undergoing percutaneous coronary intervention (PCI) by reducing inflammation and oxidative stress. This treatment is safe and does not increase adverse reactions, making it a viable option for preventing contrast-induced nephropathy (CIN).

Area of Science:

  • Cardiology
  • Nephrology
  • Pharmacology

Background:

  • Clinical options for preventing and treating contrast-induced nephropathy (CIN) are limited.
  • Statins show potential in mitigating CIN during procedures like percutaneous coronary intervention (PCI).
  • This study investigates the efficacy of atorvastatin in preserving renal function post-PCI.

Purpose of the Study:

  • To evaluate the effect of high-dose atorvastatin on renal function in patients with coronary heart disease (CHD) after PCI.
  • To compare the renal function indicators, blood routine, and adverse reactions between high-dose and conventional-dose atorvastatin groups.

Main Methods:

  • A study involving 100 elderly patients with CHD undergoing PCI.
  • Patients were divided into two groups: an experimental group (n=50) receiving 40 mg/day atorvastatin and a control group (n=50) receiving 10 mg/day atorvastatin.
  • Renal function indicators, blood routine, and adverse reactions were monitored and compared.

Main Results:

  • The high-dose atorvastatin group showed significantly lower levels of serum creatinine, blood urea nitrogen, cystatin C, hs-CRP, and IL-6.
  • The high-dose group exhibited significantly higher levels of estimated glomerular filtration rate and superoxide dismutase.
  • Both groups had an 8% incidence of adverse reactions, indicating no significant difference in safety.

Conclusions:

  • High-dose atorvastatin (40 mg/day) effectively prevents renal function damage in patients with CIN after PCI.
  • High-dose atorvastatin reduces inflammation and oxidative stress in these patients.
  • The treatment demonstrates high efficacy and safety, supporting its use in clinical practice.
Abstract

Keywords:
AtorvastatinContrast-induced nephropathyEstimated glomerular filtration ratePercutaneous coronary interventionRenal function damage

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