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Related Experiment Video

Updated: Jun 9, 2025

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Magneto-Thermal Hydrogel Swarms for Targeted Lesion Sealing.

Ziheng Chen1,2,3, Hui Chen2,3, Kaiwen Fang2,3

  • 1School of Mechatronics Engineering and Automation, Shanghai University, Shanghai, 200444, China.

Advanced Healthcare Materials
|October 25, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces magnetic microswarms for targeted lesion treatment. These magneto-thermal hydrogel particles can seal tissue perforations and deliver drugs, demonstrating potential for in vivo medical applications.

Keywords:
Magneto‐thermal hydrogelhydrogel microswarmsphase transitiontriggerable sealing

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Magnetic microswarms offer potential for in vivo medical applications like targeted lesion navigation.
  • Challenges exist in precise delivery and sealing for lesion cavity filling using microswarms.

Purpose of the Study:

  • To develop a magneto-thermal hydrogel swarm for lesion cavity filling and sealing.
  • To investigate the swarm's capabilities in targeted delivery and drug release.

Main Methods:

  • Fabrication of magnetic hydrogel particles using temperature-responsive hydrogels, tissue adhesives, and magnetic microparticles.
  • Evaluation of swarm remolding, sealing capabilities in phantom and gastric tissues.
  • Characterization of drug release profiles and in vivo/ex vivo performance for gastric ulcer treatment.

Main Results:

  • The magneto-thermal hydrogel swarm demonstrated shape adaptability and effective sealing of perforations.
  • The swarms functioned as drug carriers with temperature-modulated drug release.
  • Successful targeted delivery, adaptive filling, and sealing of gastric ulcers were achieved in ex vivo and in vivo models.

Conclusions:

  • Magneto-thermal hydrogel microswarms present a promising solution for precise lesion cavity filling and sealing.
  • The developed swarms exhibit dual functionality as sealants and controllable drug delivery systems.
  • This technology holds significant potential for advancing in vivo medical interventions.