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Related Experiment Video

Updated: Jun 9, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
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Intermittent Fasting and Fasting-mimicking Diet: Promising Strategies in Cancer Management.

Chuanqiang Zhang1, Fengqing Fu2,3, Xingchao Zhu4

  • 1Department of General Surgery, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.

Current Medicinal Chemistry
|October 25, 2024
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Summary

Intermittent fasting (IF) and fasting-mimicking diet (FMD) show promise in cancer therapy by impeding tumor growth and enhancing treatment efficacy. These dietary interventions also positively impact the tumor immune response and reduce side effects.

Keywords:
Cancercancer therapyclinical trialsfasting-mimicking dietintermittent fastingmultiple signaling pathways.

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Area of Science:

  • Oncology
  • Metabolic pathways
  • Immunology

Background:

  • Intermittent fasting (IF) and fasting-mimicking diets (FMD) are dietary interventions with potential anti-cancer effects.
  • Understanding their mechanisms is crucial for optimizing cancer treatment strategies.

Purpose of the Study:

  • To review the advancements in understanding the roles and mechanisms of IF and FMD in cancer.
  • To synthesize current findings on how IF and FMD affect tumor progression, immune response, and therapy outcomes.

Main Methods:

  • Comprehensive literature review of studies on intermittent fasting and fasting-mimicking diets in cancer.
  • Analysis of preclinical and clinical data investigating the molecular and cellular effects of IF and FMD.

Main Results:

  • IF and FMD can impede tumor growth by modulating key signaling pathways (AKT, Nrf2, AMPK).
  • These dietary interventions influence the tumor immune microenvironment by regulating immune cells (TAMs, MDSCs, T cells, B cells).
  • IF and FMD enhance the efficacy and tolerability of cancer therapies, reducing treatment-related side effects.

Conclusions:

  • IF and FMD represent promising complementary strategies in cancer therapy.
  • Clinical trials indicate safety, feasibility, and improved quality of life with IF and FMD, supporting their integration into cancer care.
  • Further research into the underlying mechanisms can refine the application of IF and FMD for improved cancer patient outcomes.