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UBL3 Interacts with PolyQ-Expanded Huntingtin Fragments and Modifies Their Intracellular Sorting

Soho Oyama1, Hengsen Zhang1,2, Rafia Ferdous1

  • 1Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-ku, Hamamatsu 431-3192, Shizuoka, Japan.

Neurology International
|October 25, 2024
PubMed
Summary

Ubiquitin-like 3 (UBL3) protein interacts with mutant huntingtin fragments (mHTT) in Huntington's disease (HD) brains. This interaction influences mHTT’s cellular sorting, offering new insights into HD pathology.

Keywords:
huntingtin proteinhuntington’s diseaseinteractionpolyglutaminesortingubiquitin-like 3

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