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Related Concept Videos

Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

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Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
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Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
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Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques01:30

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Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
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Adaptive Mechanisms in Cancer Cells02:53

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Articles linked to this work by shared authors, journal, and citation graph.

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Determinants of Postoperative Outcomes and Cost in Short-Stay Total Thyroidectomy Hospitalisations: A Retrospective Database Study.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2026
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Analysis of endoscopic orbital decompression with and without navigation for thyroid eye disease.

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Tumour-infiltrating lymphocytes do not predict survival in human papillomavirus-associated oropharyngeal squamous cell carcinoma: a single institution retrospective review.

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Related Experiment Video

Updated: Jun 9, 2025

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
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Determining Factors Which Limit Resectability in Advanced Hypopharyngeal Malignancy.

Justin M Hintze1,2,3, Eoin Cleere1,2,3, Isobel O'Riordan1,2,3

  • 1Department of Otolaryngology-Head and Neck Surgery, St. James's Hospital, Dublin, Ireland.

Head & Neck
|October 25, 2024
PubMed
Summary
This summary is machine-generated.

Preoperative imaging for hypopharyngeal cancer often suggests factors limiting surgery, but most patients are still resectable. Advanced hypopharyngeal cancers, particularly in salvage cases, should be considered for surgical resection.

Keywords:
SCChypopharyngealprevertebral fasciaresectability

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Area of Science:

  • Oncology
  • Radiology
  • Surgical Oncology

Background:

  • Preoperative radiological findings guide surgical resection decisions for hypopharyngeal cancers.
  • Assessing the predictive value of imaging characteristics for surgical resectability is crucial.

Purpose of the Study:

  • To evaluate how preoperative imaging findings correlate with the surgical resectability of hypopharyngeal cancers.
  • To determine the accuracy of imaging in predicting factors that might limit surgical intervention.

Main Methods:

  • Retrospective case-control study of 71 patients undergoing pharyngolaryngectomy.
  • Collected data included demographics, prior treatments, cancer subsite, TNM staging, and imaging/operative characteristics.

Main Results:

  • 91.1% of patients with initial inclusion criteria underwent successful resection.
  • Suspicion of prevertebral fascia invasion (30.7%) and carotid artery involvement (17.9%) on imaging did not preclude resection in most cases (79.2% and 78.6% resectable, respectively).
  • Suspicious imaging findings for prevertebral fascia invasion were associated with a higher likelihood of close surgical margins.

Conclusions:

  • High rates of surgical resectability are achievable for hypopharyngeal cancers, even with preoperative imaging suggesting limited resectability.
  • Surgery should be strongly considered for advanced hypopharyngeal cancers, especially in the salvage setting, despite concerning imaging findings.