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Updated: Jun 9, 2025

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Driving tert-butyl axial: the surprising cyclopropyl effect

Anthony R Izzotti1, James L Gleason1

  • 1Department of Chemistry, McGill University 801 SherbrookeW. H3A 0B8 Montreal QC Canada jim.gleason@mcgill.ca.

Chemical Science
|October 25, 2024
PubMed
Summary

A spirocyclic ring adjacent to a six-membered ring forces larger alkyl groups into axial positions. This conformational change, driven by torsional strain, impacts various ring systems and acyclic models.

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