Advances in Imaging for Metastatic Epidural Spinal Cord Compression: A Comprehensive Review of Detection, Diagnosis,...

Metastatic epidural spinal cord compression (MESCC) is a critical oncologic emergency caused by the invasion of metastatic tumors into the spinal epidural space, leading to compression of the spinal cord. If not promptly diagnosed and treated, MESCC can result in irreversible neurological deficits, including paralysis, significantly impacting the patient's quality of life. Early detection and timely intervention are crucial to prevent permanent damage. Imaging modalities play a pivotal role in the diagnosis, assessment of disease extent, and treatment planning for MESCC. Magnetic resonance imaging (MRI) is the current gold standard due to its superior ability to visualize the spinal cord, epidural space, and metastatic lesions. However, recent advances in imaging technologies have enhanced the detection and management of MESCC. Innovations such as functional MRI, diffusion-weighted imaging (DWI), and hybrid techniques like positron emission tomography-computed tomography (PET-CT) and PET-MRI have improved the accuracy of diagnosis, particularly in detecting early metastatic changes and guiding therapeutic interventions. This review provides a comprehensive analysis of the evolution of imaging techniques for MESCC, focusing on their roles in detection, diagnosis, and treatment planning. It also discusses the impact of these advances on clinical outcomes and future research directions in imaging modalities for MESCC. Understanding these advancements is critical for optimizing the management of MESCC and improving patient prognosis.