Autism and Migraine: A Narrative Review

Both autism spectrum disorder and migraine are heterogeneous disorders from a genetic and phenotypic perspective. Both disorders impact the patient and caregiver's quality of life. The link between autism spectrum disorder and migraine headaches has been suggested through some similarities in some genetic, structural, and psychopathological studies. However, few clinical studies looked into this association. The diagnosis of migraine in children and adolescents with autism is more challenging for several reasons, for example, the impairment in social communication that is a core feature in autism and has a high comorbidity with language disorders and/or intellectual delay. Pain expression or pain behavior is another challenging reason. This study aims to review the association between autism and migraine and to help improve the clinical assessment of children and adolescents with autism and comorbid migraine.