Efficacy of Intra-articular Super-dose Platelet-Rich Plasma Injection in Improving Pain in a Middle-Aged Sedentary...

This case study explores the use of super-dose platelet-rich plasma (PRP) in managing a meniscal tear in a 43-year-old woman with left knee pain. The patient was diagnosed with a vertical longitudinal tear of the body and posterior horn medial meniscus, confirmed through magnetic resonance imaging. Super-dose PRP, characterized by a higher platelet volume (8 ml), was administered intra-articular. Post-injection, the patient reported initial discomfort for a few days, but significant improvements in pain and range of motion (ROM) were observed within the first week. Over 12 weeks, her visual analog scale pain score decreased from 8/10 during activity to 2/10, and her ROM returned to full functionality. The case supports the hypothesis that super-dose PRP may enhance the healing process in meniscal injuries by promoting tissue healing and regeneration through the release of growth factors, angiogenesis, collagen synthesis, and inflammation modulation. This case highlights PRP's potential as a non-surgical treatment for meniscal tears. Further large-scale studies and randomized controlled trials are needed to validate these results, optimize dosing strategies, and determine which patient populations will benefit most from this innovative treatment approach.