Metabolic Reprogramming of Cancer-Associated Fibroblast in the Tumor Microenvironment: From Basics to Clinic

Area of Science:

• Oncology
• Cancer Metabolism
• Tumor Microenvironment (TME)

Background:

• Tumor cells undergo metabolic reprogramming to meet growth demands.
• Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment (TME), promoting tumor progression.
• Metabolic reprogramming in CAFs influences cancer cell metabolism through crosstalk.

Purpose of the Study:

• To review the role of CAFs in the TME.
• To elucidate the mechanisms of CAF metabolic reprogramming in cancer progression and metastasis.
• To highlight the therapeutic potential of targeting CAF metabolism in cancer treatment.

Main Methods:

• Literature review of studies on CAFs and metabolic reprogramming.
• Analysis of CAF-cancer cell metabolic crosstalk.
• Evaluation of CAF metabolic reprogramming in tumor progression and metastasis.

Main Results:

• CAFs play a significant role in shaping the TME.
• CAF metabolic reprogramming directly contributes to cancer progression and metastasis.
• Metabolic crosstalk between CAFs and cancer cells is crucial for tumor growth.

Conclusions:

• CAF metabolic reprogramming is a critical factor in cancer development.
• Targeting CAF metabolism presents a novel therapeutic strategy for cancer.
• Future research should focus on exploiting CAF metabolic reprogramming for enhanced chemotherapy and immunotherapy.