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A hybrid mock circulatory loop integrated with a LED-PIV system for the investigation of AAA compliant phantoms
Francesco Bardi1,2,3, Emanuele Gasparotti1, Emanuele Vignali1
1BioCardioLab, Bioengineering Unit, Ospedale del Cuore, Massa, Italy.
Insights
This study shows a new Hybrid-MCL with LED-PIV is effective for studying Abdominal Aortic Aneurysm (AAA) phantoms. This approach makes in-vitro cardiovascular disease research safer and more affordable.
Area of Science:
- Cardiovascular research
- Biomedical engineering
- Hemodynamics
Background:
- Cardiovascular diseases (CVD) are a major global health concern, necessitating advanced in-vitro study methods.
- Mock Circulatory Loops (MCLs) offer realistic hemodynamic replication for patient-specific data.
- Traditional Particle Image Velocimetry (PIV) is effective but expensive and requires safety precautions; High-power Light Emitting Diode illuminated PIV (LED-PIV) presents a safer, cost-effective alternative.
Purpose of the Study:
- To demonstrate the feasibility of a Hybrid-MCL combined with an LED-PIV system.
- To investigate Abdominal Aortic Aneurysm (AAA) compliant phantoms using this integrated system.
- To assess the system's performance under various physiological flow and pressure conditions.
Main Methods:
- Integration of a Hybrid-MCL with an LED-PIV system.
- Utilized two AAA phantom models: an idealized and a patient-specific model.
- Conducted experiments under diverse physiological flow and pressure conditions.
Main Results:
- Confirmed the efficacy of the Hybrid-MCL and LED-PIV setup for AAA hemodynamics.
- Observed velocity and vorticity fields across different flow rates and regions of interest.
- Validated the system's capability to investigate complex hemodynamic phenomena.
Conclusions:
- The Hybrid-MCL integrated with LED-PIV shows significant potential for in-vitro cardiovascular disease research.
- This approach enhances the affordability, accessibility, and safety of hemodynamic investigations.
- The study highlights a promising, cost-effective alternative for studying cardiovascular conditions like AAA.
Background:
Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide and require extensive investigation through in-vitro studies. Mock Circulatory Loops (MCLs) are advanced in-vitro platforms that accurately replicate physiological and pathological hemodynamic conditions, while also allowing for precise and patient-specific data collection. Particle Image Velocimetry (PIV) is the standard flow visualization technique for in-vitro studies, but it is costly and requires strict safety measures. High-power Light Emitting Diode illuminated PIV (LED-PIV) offers a safer and cheaper alternative.
Methods:
In this study, we aim to demonstrate the feasibility of a Hybrid-MCL integrated with a LED-PIV system for the investigation of Abdominal Aortic Aneurysm (AAA) compliant phantoms. We considered two distinct AAA models, namely, an idealized model and a patient-specific one under different physiological flow and pressure conditions.
Results:
The efficacy of the proposed setup for the investigation of AAA hemodynamics was confirmed by observing velocity and vorticity fields across multiple flow rate scenarios and regions of interest.
Conclusion:
The findings of this study underscore the potential impact of Hybrid-MCL integrated with a LED-PIV system on enhancing the affordability, accessibility, and safety of in-vitro CVD investigations.
