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Central Skull Base Osteomyelitis in Queensland, Australia, 2010-2020
Matthew B Eustace1,2, Maxwell Braddick2, Kylie Alcorn3
1Royal Brisbane Clinical Unit, University of Queensland Faculty of Medicine, Herston, Queensland, Australia.
Open Forum Infectious Diseases
|October 25, 2024
Summary
Central skull base osteomyelitis (CSBO) is a severe infection with high mortality. This study found advanced age and diabetes are key risk factors, with limited surgical options and significant long-term complications observed.
Area of Science:
- Infectious Diseases
- Otolaryngology
- Neurosurgery
Background:
- Central skull base osteomyelitis (CSBO) is a serious, incompletely understood infection of the cranial vault bones.
- This study examines the clinical features and outcomes of CSBO in Queensland, Australia.
Purpose of the Study:
- To describe the epidemiology, demographics, diagnosis, management, and outcomes of CSBO.
- To identify risk factors and common pathogens associated with CSBO.
Main Methods:
- Retrospective case series of 22 patients diagnosed with CSBO between 2010 and 2020.
- Data collected included epidemiological, demographic, diagnostic, management, and outcome information.
Main Results:
- The median age of patients was 73 years, with a male predominance (73%) and high comorbidity.
- Diabetes mellitus was the most common comorbidity. Pseudomonas aeruginosa and Staphylococcus aureus were the most frequent pathogens.
- The mortality rate was 31.8%, with 45.5% experiencing long-term sequelae.
Conclusions:
- Advanced age and diabetes are significant risk factors for CSBO.
- Microbiological diagnosis often relied on superficial sampling, and surgical intervention was limited.
- CSBO is associated with substantial mortality and morbidity, necessitating further research for improved management strategies.
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