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Role of Sam68 in different types of cancer (Review)

Carlos Jiménez-Cortegana1, Flora Sánchez-Jiménez1, Luis De La Cruz-Merino2

  • 1Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain.

International Journal of Molecular Medicine
|October 25, 2024
PubMed

Insights

Src-associated in mitosis 68 kDa protein (Sam68) is a key regulator in cancer progression. Targeting Sam68 shows promise for developing novel cancer therapies by inhibiting tumor growth and metastasis.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Src-associated in mitosis 68 kDa protein (Sam68) is encoded by the KHDRBS1 gene.
  • Sam68 participates in gene expression, RNA processing, and cell signaling.
  • Sam68 is implicated in various diseases, notably cancer.

Purpose of the Study:

  • To summarize Sam68's role in cancer models and patients.
  • To elucidate the molecular mechanisms of Sam68's oncogenic potential.
  • To discuss the efficacy of antitumor agents targeting Sam68.

Main Methods:

  • Review of existing literature on Sam68 in cancer.
  • Analysis of Sam68's involvement in tumor cell proliferation, progression, and metastasis.
  • Evaluation of Sam68's role in cancer stem cell self-renewal.

Main Results:

  • Sam68 is involved in tumor cell proliferation, progression, and metastasis.
  • Sam68 plays a role in regulating cancer stem cell self-renewal.
  • Sam68 demonstrates oncogenic potential through various molecular mechanisms.

Conclusions:

  • Sam68 is a significant factor in cancer development and progression.
  • Sam68 represents a promising therapeutic target for cancer treatment.
  • Targeting Sam68 may offer a strategy to reduce malignant effects during tumorigenesis.
Keywords:
KHDRBS1RNA‑binding proteinSam68cancercancer‑stem cellstumorigenesis

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