Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leukemic samples characteristics associated with clonogenic growth.

J Birkmann, U Früh, V Hofmann

    Leukemia Research
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Challenging behaviour in students with intellectual disabilities: the role of individual and classmates' communication skills.

    Journal of intellectual disability research : JIDR·2022
    Same author

    Combining ACL Reconstruction and Refixation: the Single Anteromedial Bundle Biological Augmentation and Refixation (SAMBBAR) Technique.

    Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca·2022
    Same author

    Off-label use of orthopedical trauma implants in a low-income country.

    International orthopaedics·2021
    Same author

    No implant, no solution, lost cases to surgery: orthopedic trauma triage for surgery in an NGO hospital in Sierra Leone.

    Archives of orthopaedic and trauma surgery·2021
    Same author

    War surgery in Afghanistan: a model for mass causalities in terror attacks?

    International orthopaedics·2020
    Same author

    Abortion in women with Down syndrome.

    Journal of intellectual disability research : JIDR·2020
    Same journal

    Multispecialty referral patterns to a clonal hematopoiesis clinic: Who, what, and why?

    Leukemia research·2026
    Same journal

    A multicenter real-world study of clinical outcomes in octogenarians and older patients with acute myeloid leukemia.

    Leukemia research·2026
    Same journal

    FLAMSA versus FLAG-IDA as salvage therapy in adults with relapsed/refractory acute myeloid leukemia and acute lymphoblastic leukemia: A single-center real-world retrospective study.

    Leukemia research·2026
    Same journal

    CD244 modulates bone marrow infiltrating CD8<sup>+</sup> T cells and serves as a prognostic and immunotherapeutic target in acute myeloid leukemia.

    Leukemia research·2026
    Same journal

    Long-term remission and survival in older adults with IDH-mutated acute myeloid leukemia treated with IDH inhibitors.

    Leukemia research·2026
    Same journal

    Real-world outcomes of plasmablastic lymphoma: Treatment approaches and survival outcomes in the PLASMABLAT-001 cohort.

    Leukemia research·2026
    See all related articles

    Leukemic cells from previously treated patients showed significantly better in-vitro growth. Treatment status emerged as the primary factor influencing leukemia cell growth in culture.

    Area of Science:

    • Hematology
    • Oncology
    • Cell Biology

    Background:

    • In-vitro culture of leukemia cells is crucial for understanding disease biology and treatment response.
    • Predicting successful leukemia cell growth in culture can optimize experimental design and interpretation.

    Purpose of the Study:

    • To identify readily assessable characteristics correlating with in-vitro growth of leukemia cells.
    • To determine factors influencing the success of leukemia cell culturing.

    Main Methods:

    • Analysis of 100 leukemic samples for in-vitro growth.
    • Assessment of growth based on cluster and colony counts per culture dish.
    • Multivariate analysis to identify significant predictive factors.

    Main Results:

    Related Experiment Videos

    • Successful in-vitro growth was achieved in 68% of samples.
    • Leukemic cells from previously treated patients exhibited significantly better growth.
    • Peripheral blood cells showed a slight growth advantage over bone marrow cells when considering cluster growth.

    Conclusions:

    • Patient treatment status is the most significant factor predicting in-vitro leukemia cell growth.
    • While cell source (peripheral blood vs. bone marrow) shows a minor influence, treatment history is paramount.
    • Morphological subtype and pre-culture proliferation kinetics did not impact cloning success.