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Heat, cold and inflammation.

K L Schmidt, V R Ott, G Röcher

    Zeitschrift Fur Rheumatologie
    |November 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Therapeutic heat and cold applications for rheumatic diseases show varied effects on inflammation. While cold may help acute inflammation, heat benefits chronic conditions, necessitating careful application.

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    Area of Science:

    • Rheumatology
    • Immunology
    • Pharmacology

    Background:

    • Therapeutic heat and cold are common in rheumatic diseases but their application in joint inflammation is empirical.
    • Systemic and local heat/cold applications have shown complex effects on experimentally induced inflammations in animal models.

    Purpose of the Study:

    • To investigate the effects of systemic hyperthermia and local heat/cold applications on various experimentally induced inflammatory conditions.
    • To determine the efficacy and potential adverse effects of heat and cold therapy in different types of inflammation.

    Main Methods:

    • Animal experiments were conducted using models such as dextran edema, formol edema, kaolin edema, carrageenan edema, and adjuvant arthritis.
    • Systemic hyperthermia and local heat/cold applications were applied to assess their impact on inflammatory responses.

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    Main Results:

    • Some inflammations were significantly depressed by heat/cold, indicating therapeutic potential.
    • Conversely, heat and cold can exacerbate inflammation under certain conditions; whole-body hyperthermia demonstrated immunosuppressive effects.
    • Acute exudative inflammations responded better to cold, while chronic, torpid inflammations were better influenced by heat.
    • Prostaglandin-mediated inflammations can be aggravated by cold due to stimulated synthesis, and acute exudative processes by heat.

    Conclusions:

    • Heat and cold therapy in rheumatic diseases require careful, well-defined application ranges.
    • The choice between heat and cold therapy should be based on the specific type and characteristics of the inflammation.