Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytoskeletal Linker Proteins - Plakins01:09

Cytoskeletal Linker Proteins - Plakins

2.3K
Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
2.3K
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

3.0K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
3.0K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

3.4K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.4K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

5.7K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
5.7K
Enlargement of the Plasma Membrane01:22

Enlargement of the Plasma Membrane

1.9K
Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...
1.9K
Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

8.5K
Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
8.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical features of 170 Chinese scabies cases and the therapeutic efficacy of sulfur ointment.

PLoS neglected tropical diseases·2026
Same author

mTORC1-mediated inhibition of AMBRA1/PINK1/Parkin-dependent mitophagy contributes to renal podocyte injury in trichloroethylene-sensitized mice.

Toxicology and applied pharmacology·2026
Same author

Serum amyloid A1 activates the NLRP3 inflammasome via TLR2 to mediate trichloroethylene-induced immune kidney injury.

Archives of biochemistry and biophysics·2026
Same author

Advances in the application of ionic liquids and deep eutectic solvents in chitosan-based packaging systems: Trends and opportunities.

Carbohydrate polymers·2026
Same author

Hedgehog pathway activity downstream of Smoothened is regulated specifically by basal ciliary PKA.

Cellular & molecular biology letters·2026
Same author

Atom-economic molecular design of vanillin-based tetraene for tunable polyesters <i>via</i> thiol-ene click polymerization.

Chemical communications (Cambridge, England)·2026

Related Experiment Video

Updated: Jun 9, 2025

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

9.7K

PKD2: An Important Membrane Protein in Organ Development.

Shuo Wang1,2, Yunsi Kang1,2, Haibo Xie1,2

  • 1MoE Key Laboratory of Evolution and Marine Biodiversity, Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao 266003, China.

Cells
|October 25, 2024
PubMed
Summary

Polycystic kidney disease 2 (PKD2) protein is vital for organ development and function, acting as an ion channel. Research in model animals reveals its essential roles in asymmetry, kidney health, and cardiovascular and reproductive systems.

Keywords:
PKD2calciumcilialeft–right asymmetryorgan developmentpolycystic kidney disease

More Related Videos

Immunostaining Phospho-epitopes in Ciliated Organs of Whole Mount Zebrafish Embryos
08:42

Immunostaining Phospho-epitopes in Ciliated Organs of Whole Mount Zebrafish Embryos

Published on: February 19, 2016

8.0K
Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins
11:11

Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins

Published on: June 15, 2018

8.3K

Related Experiment Videos

Last Updated: Jun 9, 2025

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

9.7K
Immunostaining Phospho-epitopes in Ciliated Organs of Whole Mount Zebrafish Embryos
08:42

Immunostaining Phospho-epitopes in Ciliated Organs of Whole Mount Zebrafish Embryos

Published on: February 19, 2016

8.0K
Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins
11:11

Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins

Published on: June 15, 2018

8.3K

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Physiology

Background:

  • Polycystic kidney disease 2 (PKD2) is an ion channel protein initially linked to autosomal dominant polycystic kidney disease (ADPKD).
  • PKD2 exhibits broad tissue expression and is conserved across species, indicating fundamental biological importance.
  • Its role extends beyond kidney disease to crucial functions in development and homeostasis.

Purpose of the Study:

  • To provide an overview of recent advances in PKD2 function across key model organisms.
  • To highlight the specific roles of PKD2 in organ development, renal homeostasis, cardiovascular development, and reproductive signaling.
  • To discuss future research directions for PKD2.

Main Methods:

  • Review of recent scientific literature on PKD2 function in model animals.
  • Focus on studies investigating PKD2's role in left-right organ asymmetry.
  • Analysis of research concerning PKD2 in renal homeostasis, cardiovascular development, and reproduction.

Main Results:

  • PKD2 is essential for establishing left-right organ asymmetry during development.
  • The protein plays a critical role in maintaining renal homeostasis and cardiovascular development.
  • PKD2 is involved in signal transduction pathways related to reproduction and mating.

Conclusions:

  • PKD2 is a multifunctional protein with critical roles in development and physiological processes.
  • Understanding PKD2 function in model organisms provides insights into human health and disease.
  • Further research into PKD2 holds promise for therapeutic strategies and understanding fundamental biology.