Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Analysis of Dual-miRNA Mediated Stimulation of Nucleus Pulposus and Bone Marrow Derived Stem Cells for Intervertebral Disc Repair.

JOR spine·2026
Same author

PolyGraph - Flexible, Biocompatible & Electrically Optimized Graphene-Polymer Composites for Next-Generation Neural Interfaces.

Advanced healthcare materials·2026
Same author

Polycaprolactone-Itaconic Acid Resins for Additive Manufacturing of Environmentally Degradable 3D and 4D Materials by Thiol-ene Photopolymerization.

Macromolecules·2026
Same author

RAFT-Mediated 3D Printing of Polylactones/Itaconate Elastomers with Polypeptide Surface Functionalization.

ACS polymers Au·2026
Same author

Enhancing Biocompatibility and Biophysical Properties of Three-Dimensional Collagen Scaffolds Using Nonthermal Plasma Treatment.

ACS biomaterials science & engineering·2026
Same author

Lesion-targeted, severity-responsive nanoparticle delivery for RNA therapy in osteoarthritis.

Nature nanotechnology·2026

Related Experiment Video

Updated: Jun 9, 2025

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.0K

Shear-Thinning Extrudable Hydrogels Based on Star Polypeptides with Antimicrobial Properties.

Dimitrios Skoulas1, Muireann Fallon2, Katelyn J Genoud3,4

  • 1Department of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, D02 YN77 Dublin, Ireland.

Gels (Basel, Switzerland)
|October 25, 2024
PubMed
Summary

New antimicrobial hydrogels made from star block copolypeptides show low toxicity and effective infection-fighting properties. The best-performing hydrogel features a statistical inner block, offering superior physical and biological characteristics for advanced wound care.

Keywords:
antimicrobial potencyhydrogelspolypeptidesstar polymers

More Related Videos

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde
07:04

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

2.4K
Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

28.9K

Related Experiment Videos

Last Updated: Jun 9, 2025

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.0K
Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde
07:04

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

2.4K
Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

28.9K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Increasing infections necessitate advanced antimicrobial materials.
  • Hydrogels offer potential due to tunable properties and low toxicity.
  • Shear-thinning behavior is crucial for injectability and wound dressing applications.

Purpose of the Study:

  • To synthesize and characterize 8-arm star block copolypeptides for antimicrobial hydrogel applications.
  • To investigate the impact of inner block architecture (individual vs. statistical) on hydrogel properties.
  • To evaluate the cytotoxicity and antimicrobial efficacy of the developed hydrogels.

Main Methods:

  • Synthesis of three 8-arm star block copolypeptides using Ring Opening Polymerization (ROP) of N-carboxyanhydrides (NCAs).
  • Characterization of hydrogel morphology using Scanning Electron Microscopy (SEM).
  • Assessment of viscoelastic properties, water uptake, syringe extrudability, cytotoxicity, and antimicrobial activity against *Escherichia coli* and *Staphylococcus aureus*.

Main Results:

  • All synthesized star block copolypeptides formed hydrogels with porous morphology.
  • The copolypeptide with a statistical inner block of L-lysine and L-tyrosine exhibited superior viscoelasticity, water uptake, and syringe extrudability.
  • This optimized hydrogel demonstrated no cytotoxicity and significant antimicrobial activity, reducing bacterial viability by 1.5-log (*E. coli*) and 2.6-log (*S. aureus*).

Conclusions:

  • Structural control in star block copolypeptides is key to optimizing hydrogel performance.
  • The statistical inner block architecture significantly enhances physical and biological properties.
  • These novel hydrogels show promise as effective, low-toxicity antimicrobial materials for combating infections.