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Hydrogel-Based Vascularized Organ Tissue Engineering: A Systematized Review on Abdominal Organs
Filippos F Karageorgos1, Maria Alexiou1, Georgios Tsoulfas1
1Department of Transplantation Surgery, Center for Research and Innovation in Solid Organ Transplantation, Aristotle University of Thessaloniki School of Medicine, 54642 Thessaloniki, Greece.
Gels (Basel, Switzerland)
|October 25, 2024
Summary
This review explores hydrogel-based vascularized organ tissue engineering for abdominal organs like the liver and pancreas. While promising, challenges remain in creating fully functional, long-lasting engineered organs.
Area of Science:
- Biomedical Engineering
- Tissue Engineering
- Regenerative Medicine
Background:
- Tissue engineering offers alternatives to organ transplantation.
- Applications include disease modeling and drug discovery.
- Focus on generating functional organs and tissues.
Purpose of the Study:
- Review hydrogel-based vascularized organ tissue engineering.
- Focus on abdominal organs: liver, pancreas, kidneys, intestine, stomach, spleen.
Main Methods:
- Comprehensive literature search of the Scopus database.
- Included studies on hydrogel-based vascularized organ tissue engineering.
- Latest search conducted on September 1, 2024.
Main Results:
- 18 studies were included in the review.
- Liver/hepatic tissue: 10 studies.
- Pancreas/islet tissue: 5 studies.
- Kidney/renal tissue: 3 studies.
- Intestine/bowel tissue: 1 study.
- Stomach/gastric tissue: 1 study.
- Spleen tissue: 0 studies.
Conclusions:
- Hydrogels serve as ideal, biocompatible scaffolds.
- Organ tissue engineering is a rapidly advancing field.
- Significant obstacles persist in creating fully functional, durable organs.
