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Development of Personalised Immediate-Release Gel-Based Formulations Using Semi-Solid Extrusion
Morenikeji Aina1, Fabien Baillon1, Romain Sescousse1
1RAPSODEE, IMT Mines Albi, CNRS, University of Toulouse, 81013 Albi, France.
Gels (Basel, Switzerland)
|October 25, 2024
Summary
3D printing creates personalized gel medications for preterm infants, improving dosing accuracy and safety. This novel approach ensures reliable drug delivery, overcoming limitations of manual dose adjustments.
Area of Science:
- Pharmaceutical Technology
- Biomaterials Science
- Neonatal Medicine
Background:
- Manual dose adjustments in neonates are prone to errors, contamination, and reduced precision.
- Optimizing therapeutic outcomes requires accurate drug delivery, especially for vulnerable populations like preterm infants.
- Existing methods for pediatric dosing lack the personalization needed for optimal patient care.
Purpose of the Study:
- To develop and evaluate personalized, gel-based caffeine dosage forms using semi-solid extrusion 3D printing (SSE 3DP).
- To assess the precision, reproducibility, and drug release characteristics of the 3D-printed dosage forms.
- To demonstrate the potential of SSE 3DP for tailored neonatal medication.
Main Methods:
- Utilized agar and hydroxypropyl methylcellulose to formulate hydrogels with optimal rheological properties for SSE 3DP.
- Designed and printed personalized caffeine gel dosage forms with precise volume and content adjustments for a specific neonate.
- Conducted reproducibility assessments across three production batches and performed forced degradation studies.
Main Results:
- The hydrogel formulation exhibited excellent printability and shape retention.
- Achieved high caffeine recovery (103.46%) in a personalized dose, demonstrating precise drug content control.
- Production batches showed minimal variability, confirming process reproducibility.
- Degradation studies indicated caffeine's chemical integrity within the gel matrix.
- Printed dosage forms exhibited immediate-release profiles, with >80% caffeine released within 45 minutes.
Conclusions:
- Semi-solid extrusion 3D printing offers a precise and reproducible method for creating personalized gel-based drug delivery systems.
- This technology overcomes the limitations of traditional manual dosing, enhancing safety and efficacy in neonatal care.
- 3D-printed gel formulations hold significant promise for tailored pharmaceutical solutions, particularly for preterm infants.
Keywords:
agarbatch variabilitycaffeineforced degradationhydroxypropyl methylcellulose (HPMC)immediate releasepersonalised medicinesemi-solid extrusionstabilityMore Related Videos
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