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Updated: Jun 9, 2025

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
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XAI-Augmented Voting Ensemble Models for Heart Disease Prediction: A SHAP and LIME-Based Approach
Nermeen Gamal Rezk1, Samah Alshathri2, Amged Sayed3,4
1Department of Computer Science and Engineering, Faculty of Engineering, Kafrelsheikh University, Kafr_El_Sheikh 6860404, Egypt.
Abstract:
Ensemble Learning (EL) has been used for almost ten years to classify heart diseases, but it is still difficult to grasp how the "black boxes", or non-interpretable models, behave inside. Predicting heart disease is crucial to healthcare, since it allows for prompt diagnosis and treatment of the patient's true state. Nonetheless, it is still difficult to forecast illness with any degree of accuracy. In this study, we have suggested a framework for the prediction of heart disease based on Explainable artificial intelligence (XAI)-based hybrid Ensemble Learning (EL) models, such as LightBoost and XGBoost algorithms. The main goals are to build predictive models and apply SHAP (SHapley Additive expPlanations) and LIME (Local Interpretable Model-agnostic Explanations) analysis to improve the interpretability of the models. We carefully construct our systems and test different hybrid ensemble learning algorithms to determine which model is best for heart disease prediction (HDP). The approach promotes interpretability and transparency when examining these widespread health issues. By combining hybrid Ensemble learning models with XAI, the important factors and risk signals that underpin the co-occurrence of heart disease are made visible. The accuracy, precision, and recall of such models were used to evaluate their efficacy. This study highlights how crucial it is for healthcare models to be transparent and recommends the inclusion of XAI to improve interpretability and medical decisionmaking.
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