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Diagnostic Performance of Visionix VX120+ Platform for Dry Eye Screening
Elena Martínez-Plaza1,2, Laura Barberán-Bernardos1, Ainhoa Molina-Martín1
1Group of Optics and Visual Perception, Department of Optics, Pharmacology and Anatomy, University of Alicante, 03690 Alicante, Spain.
Diagnostics (Basel, Switzerland)
|October 25, 2024
Summary
The Visionix VX120+ device shows potential for dry eye screening using non-invasive tear break-up time (NIBUT50%), but should not replace fluorescein tear break-up time (FBUT) measurements.
Area of Science:
- Ophthalmology
- Diagnostic Imaging
- Ocular Surface Disease
Background:
- Dry eye disease (DED) diagnosis relies on accurate clinical assessments.
- Non-invasive methods for evaluating tear film stability are crucial for DED diagnosis.
- Existing diagnostic tools require validation for new technologies.
Purpose of the Study:
- To assess the diagnostic accuracy of the Visionix VX120+ for dry eye disease.
- To establish reference values for tear meniscus height (TMH) and non-invasive tear break-up time (NIBUT).
- To compare NIBUT measurements with fluorescein tear break-up time (FBUT).
Main Methods:
- Fifty-eight subjects (34 DED, 24 control) were enrolled.
- Visionix VX120+ measured TMH, first NIBUT, and NIBUT50%.
- Slit-lamp measured FBUT; ROC curves and Bland-Altman analysis were used.
Main Results:
- Area under the curve values were 0.62 (TMH), 0.60 (first NIBUT), and 0.70 (NIBUT50%).
- Optimal cut-off values showed varying sensitivity and specificity for each parameter.
- Bland-Altman analysis indicated NIBUT measurements are not interchangeable with FBUT.
Conclusions:
- Non-invasive tear break-up time 50% (NIBUT50%) shows promise as a dry eye screening tool.
- The NIBUT measurements from the Visionix VX120+ are not equivalent to FBUT.
- Further validation is needed for NIBUT50% in DED screening.
