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Flower-Shaped Plasma Cells in Multiple Myeloma with Morphological Heterogeneity
Hiroki Hosoi1,2, Misato Tane1, Makiko Sogabe1
1Department of Hematology/Oncology, Wakayama Medical University, Wakayama 641-8509, Japan.
Background:
Flower-shaped nuclei in plasma cells are rare in multiple myeloma.
Case Presentation:
We report on an 88-year-old male who presented with a mass lesion in the clavicular region. A biopsy of the mass revealed an increase in mature plasma cells with round nuclei. In contrast, a bone marrow examination showed increased plasma cells with flower-shaped nuclei. The patient tested negative for human T-lymphotropic virus type-1 and was diagnosed with multiple myeloma.
Conclusions:
While multiple myeloma is known for intra-tumor heterogeneity, reports of morphological heterogeneity based on the site of tumor sampling are limited. In this case, the presence of plasma cells with flower-shaped nuclei enabled the identification of site-dependent morphological tumor heterogeneity.
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