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Radiation-Induced Breast Angiosarcoma-A Single-Institution Experience.

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Radiation-induced breast angiosarcoma (RIBAS) is a rare complication of breast cancer radiotherapy. This study highlights RIBAS

Keywords:
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Area of Science:

  • Oncology
  • Radiotherapy
  • Surgical Oncology

Background:

  • Radiation-induced breast angiosarcoma (RIBAS) is a rare but serious adverse event following breast cancer radiotherapy.
  • The incidence of RIBAS is less than 0.3% of patients treated with adjuvant radiotherapy for breast cancer.
  • Limited data exist on RIBAS presentation, management, and outcomes due to its rarity.

Purpose of the Study:

  • To report the incidence, clinical presentation, management strategies, and outcomes of RIBAS at a specialized cancer center.
  • To analyze treatment outcomes, including local recurrence, distant metastasis, and overall survival.
  • To emphasize the importance of prompt diagnosis and radical surgical management for improving patient prognosis.

Main Methods:

  • Retrospective review of 10,834 breast cancer patients treated between January 2013 and June 2024.
  • Inclusion criteria: breast-conserving surgery, postoperative irradiation, development of angiosarcoma in the irradiated area at least 3 years post-radiotherapy, and absence of distant metastases at diagnosis.
  • Analysis of incidence, latency period, tumor characteristics, management, local recurrence, distant metastasis, and survival outcomes.

Main Results:

  • Nine female patients with RIBAS were identified, with a median age of 64 years.
  • Median latency from irradiation to RIBAS diagnosis was 64 months; median tumor size was 55 mm.
  • High rates of local recurrence (77.8%) and distant metastasis (3 patients) were observed. Median overall survival was 31 months, with a 3-year survival rate of 15.2%.

Conclusions:

  • RIBAS is a rare but increasingly recognized complication of breast cancer radiotherapy, characterized by an aggressive clinical course.
  • High rates of local recurrence underscore the need for effective management strategies.
  • Prompt diagnosis and radical surgical resection with wide margins are crucial for improving outcomes in patients with RIBAS.