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Related Experiment Video

Updated: Jun 9, 2025

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Association Between Glaucoma and Brain Structural Connectivity Based on Diffusion Tensor Tractography: A

Lian Shu¹, Xiaoxiao Chen¹, Xinghuai Sun^1,2,3

¹Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China.

|October 25, 2024

Summary

This study explored the causal link between glaucoma and brain structural connectivity using Mendelian randomization. Findings suggest a potential bidirectional relationship, offering new insights into glaucoma

Keywords:

Mendelian randomization diffusion tensor imaging diffusion tensor tractography glaucoma neurodegenerative disease structural connectivity

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Last Updated: Jun 9, 2025

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

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Published on: November 8, 2012

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

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Published on: August 26, 2014

Area of Science:

Neuroscience
Ophthalmology
Genetics

Background:

Glaucoma is a neurodegenerative disease impacting the brain beyond the visual system.
Previous research suggested links between glaucoma and brain structural connectivity but lacked causal evidence.

Purpose of the Study:

To investigate potential causal associations between glaucoma and brain structural connectivity.
To clarify the directionality of these relationships using a bidirectional approach.

Main Methods:

A bidirectional Mendelian randomization (MR) study was performed.
Utilized genetic variations as instrumental variables from FinnGen and UK Biobank datasets.
Employed inverse-variance weighted methods and sensitivity analyses.

Main Results:

Forward MR identified causal links between glaucoma and three brain connectivities (SN-thalamus, DAN-putamen, LN network).
Inverse MR revealed thirteen brain structural connectivity traits potentially influencing glaucoma risk.
Sensitivity analyses confirmed the robustness of the findings, showing no significant pleiotropy or heterogeneity.

Conclusions:

Suggestive evidence supports a potential causal relationship between glaucoma risk and brain structural connectivity.
Findings contribute to understanding the neurodegenerative mechanisms underlying glaucoma.