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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
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Association between Left Atrial Function and Survival in Systemic Sclerosis
Adrian Giucă1,2,3, Xavier Galloo1,4, Maria Chiara Meucci1,5
1Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands.
Journal of Cardiovascular Development and Disease
|October 25, 2024
Summary
Left atrial reservoir strain (ƐR) is a new echocardiography measure that predicts survival in systemic sclerosis (SSc) patients. Lower ƐR values (≤30%) indicate a poorer prognosis and increased mortality risk in SSc.
Area of Science:
- Cardiology
- Rheumatology
- Medical Imaging
Background:
- Systemic sclerosis (SSc) is an autoimmune disease with frequent cardiac involvement, negatively impacting prognosis.
- Left ventricular diastolic dysfunction is common in SSc patients.
- Left atrial reservoir strain (ƐR) is a novel echocardiographic parameter for assessing diastolic function.
Purpose of the Study:
- To evaluate the prognostic significance of ƐR in a large, multicenter cohort of SSc patients.
- To determine if ƐR can improve risk stratification in SSc.
Main Methods:
- Echocardiography, including ƐR measurement, was performed on 311 SSc patients at their initial visit.
- Patients were followed for a median of 132 months for all-cause mortality.
- Statistical analyses included spline curve analysis and multivariable Cox regression.
Main Results:
- An ƐR cut-off of 30% was identified, with ƐR ≤ 30% associated with significantly lower 10-year survival (71% vs. 88%).
- Multivariable analysis confirmed ƐR as an independent predictor of mortality (HR 1.830, p=0.039).
- Age, female sex, and diffusing lung capacity for carbon monoxide also independently predicted outcomes.
Conclusions:
- Left atrial reservoir strain (ƐR) is an independent prognostic marker in systemic sclerosis.
- ƐR measurement can aid in optimizing risk stratification for SSc patients.
- This novel parameter offers valuable insights into cardiac health and survival in SSc.
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