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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

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Association between Left Atrial Function and Survival in Systemic Sclerosis.

Adrian Giucă1,2,3, Xavier Galloo1,4, Maria Chiara Meucci1,5

  • 1Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands.

Journal of Cardiovascular Development and Disease
|October 25, 2024
PubMed
Summary
This summary is machine-generated.

Left atrial reservoir strain (ƐR) is a new echocardiography measure that predicts survival in systemic sclerosis (SSc) patients. Lower ƐR values (≤30%) indicate a poorer prognosis and increased mortality risk in SSc.

Keywords:
Systemic sclerosisleft atrial reservoir strain

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Area of Science:

  • Cardiology
  • Rheumatology
  • Medical Imaging

Background:

  • Systemic sclerosis (SSc) is an autoimmune disease with frequent cardiac involvement, negatively impacting prognosis.
  • Left ventricular diastolic dysfunction is common in SSc patients.
  • Left atrial reservoir strain (ƐR) is a novel echocardiographic parameter for assessing diastolic function.

Purpose of the Study:

  • To evaluate the prognostic significance of ƐR in a large, multicenter cohort of SSc patients.
  • To determine if ƐR can improve risk stratification in SSc.

Main Methods:

  • Echocardiography, including ƐR measurement, was performed on 311 SSc patients at their initial visit.
  • Patients were followed for a median of 132 months for all-cause mortality.
  • Statistical analyses included spline curve analysis and multivariable Cox regression.

Main Results:

  • An ƐR cut-off of 30% was identified, with ƐR ≤ 30% associated with significantly lower 10-year survival (71% vs. 88%).
  • Multivariable analysis confirmed ƐR as an independent predictor of mortality (HR 1.830, p=0.039).
  • Age, female sex, and diffusing lung capacity for carbon monoxide also independently predicted outcomes.

Conclusions:

  • Left atrial reservoir strain (ƐR) is an independent prognostic marker in systemic sclerosis.
  • ƐR measurement can aid in optimizing risk stratification for SSc patients.
  • This novel parameter offers valuable insights into cardiac health and survival in SSc.