Correlation between Human Embryo Morphokinetics Observed through Time-Lapse Incubator and Life Birth Rate

Area of Science:

• Reproductive Biology
• Embryology
• In Vitro Fertilization

Background:

• Assessing embryo development is crucial for predicting pregnancy outcomes.
• Time-lapse monitoring offers detailed insights into embryo morphokinetics.
• Understanding variations in embryo development can improve success rates.

Purpose of the Study:

• To investigate if variations in sequential embryo development times predict pregnancy success.
• To identify specific morphokinetic parameters of implanting embryos.
• To compare embryo development between successful and unsuccessful implantation groups.

Main Methods:

• Prospective double-arm study involving 89 embryos cultured in an Esco Miri time-lapse incubator.
• Embryos divided into two groups: Lot A (successful implantation, live birth rate) and Lot B (no implantation).
• Analysis of morphokinetic parameters and embryo grading.

Main Results:

• No statistically significant differences in sequential embryo development timings between groups (p > 0.01).
• Oocyte characteristics showed a statistically significant difference (p = 0.0029).
• Embryo grading revealed an extremely statistically significant difference (p < 0.01).

Conclusions:

• Sequential embryo timings, while not statistically significant, suggest potential predictive value.
• Embryo morphokinetics, particularly grading, holds significant predictive potential for pregnancy.
• Further exploration of morphokinetic parameters may enhance pregnancy prediction in IVF.