Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biofilms01:29

Biofilms

1
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
1

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrostriction-driven phase instability enables giant pseudo-piezoelectricity in Hf<sub>0.5</sub>Zr<sub>0.5</sub>O<sub>2X</sub>.

Science advances·2026
Same author

Potential Applications of Additive Manufacturing in Intervertebral Disc Replacement Using Gyroid Structures with Several Thermoplastic Polyurethane Filaments.

Biomedicines·2026
Same author

Effect of thin porous ceramic coatings on implant stability: a comparative study of GB14 and β-TCP with and without Cu.

Journal of materials science. Materials in medicine·2026
Same author

The IADR Policy Statement on Antimicrobial Resistance.

Journal of dental research·2025
Same author

Engineering intervertebral disc replacements using 3D-printed open Gyroid architectures.

Biomedical materials (Bristol, England)·2025
Same author

7T <sup>19</sup>F/<sup>1</sup>H MRI with perfluorocarbon-labeled immune cells in pigs: Pilot results with a dedicated twin-array system with pTX support.

Magnetic resonance in medicine·2025

Related Experiment Video

Updated: Jun 9, 2025

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

3.0K

Suspension-Sprayed Calcium Phosphate Coatings with Antibacterial Properties.

Maria Carolina Lanzino1, Long-Quan R V Le2, Anika Höppel3

  • 1Institute for Manufacturing Technologies of Ceramic Components and Composites (IFKB), University of Stuttgart, 70569 Stuttgart, Germany.

Journal of Functional Biomaterials
|October 25, 2024
PubMed
Summary

Copper-doped calcium phosphate coatings enhance bone integration and exhibit strong antibacterial properties, reducing implant failure risks. These advanced coatings promote bone growth and combat bacterial contamination for improved patient outcomes.

Keywords:
CaPantimicrobial activitycoatingjointsupraparticles

More Related Videos

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
10:43

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

9.0K
2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition
06:02

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

Published on: December 26, 2016

10.3K

Related Experiment Videos

Last Updated: Jun 9, 2025

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

3.0K
High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
10:43

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

9.0K
2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition
06:02

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

Published on: December 26, 2016

10.3K

Area of Science:

  • Biomaterials Engineering
  • Orthopedic Implants
  • Nanotechnology

Background:

  • Implant failure often results from poor osteointegration and bacterial contamination, leading to loosening.
  • Bioconductive coatings promote bone growth and tissue bonding, enhancing implant stability.
  • Incorporating antibacterial agents into calcium phosphate (CaP) coatings offers a dual approach to improve implant success.

Purpose of the Study:

  • To develop enhanced calcium phosphate (CaP) ceramic coatings with antibacterial properties using copper-doped supraparticles.
  • To increase coating porosity and evaluate the antibacterial efficacy of different Cu-doped supraparticles.
  • To assess the biocompatibility of the developed coatings with human osteosarcoma cells (MG63).

Main Methods:

  • Copper-doped CaP supraparticles were synthesized via spray-drying.
  • CaP ceramic coatings with incorporated supraparticles were fabricated using high-velocity suspension flame spraying (HVSFS).
  • Coating porosity, biocompatibility (MG63 cells), and antimicrobial activity against Escherichia coli and Staphylococcus aureus were evaluated.

Main Results:

  • Achieved a minimum coating porosity of 13%, enhanced up to 16% with supraparticle incorporation.
  • Cu-doped CaP coatings demonstrated good biocompatibility, with no significant reduction in viable MG63 cells compared to controls.
  • Significant reduction in both Gram-positive and Gram-negative bacterial strains was observed on Cu-doped coatings.

Conclusions:

  • Cu-doped CaP supraparticles successfully integrated into HVSFS coatings, enhancing porosity and providing potent antibacterial effects.
  • The developed coatings show promise for improving osteointegration and preventing implant-associated infections.
  • This approach offers a viable strategy for creating next-generation orthopedic implants with improved clinical performance.