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Randomized Clinical Trial: Bone Bioactive Liquid Improves Implant Stability and Osseointegration
Ashraf Al Madhoun1, Khaled Meshal2, Neus Carrió3
1Department of Animal and Imaging Core Facilities, Dasman Diabetes Institute, Dasman 15462, Kuwait.
Journal of Functional Biomaterials
|October 25, 2024
Summary
A bone bioactive liquid (BBL) significantly improved dental implant stability and reduced patient pain. This treatment enhances bone formation and implant longevity, offering promising results for patient outcomes.
Area of Science:
- Biomaterials Science
- Dental Implantology
- Regenerative Medicine
Background:
- Implant stability is critical for success, but compromised by poor bone quality and infection.
- Ensuring long-term implant performance is vital for patient satisfaction and quality of life.
Purpose of the Study:
- To evaluate the efficacy of a bone bioactive liquid (BBL) on the Galaxy TS dental implant.
- To assess BBL's impact on implant stability, osseointegration, and patient pain levels.
Main Methods:
- A multicenter, randomized, double-blind clinical trial.
- Evaluated initial stability quotient (ISQ), CBCT scans, and pain scores.
- Utilized SEM, AFM, and in vitro studies on stem cells and macrophages.
Main Results:
- BBL treatment led to significantly lower pain scores by day 7 (p < 0.00001).
- Improved implant stability (ISQ > 62.00 ± 0.59) by day 30 (p < 8 × 10-7).
- Enhanced bone area ratio by day 60 and promoted osteogenesis in vitro.
Conclusions:
- BBL treatment significantly enhances Galaxy TS implant stability and bone formation.
- BBL reduces post-operative pain and may improve implant longevity through surface and immunomodulatory effects.
- This bioactive liquid shows promise for improving dental implant outcomes.
